Ppara - peroxisome proliferator activated receptor alpha Gene

Also Known as PPAR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25747

About Ppara

Primary_assembly 7: 116,832,756-116,895,346 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 455 orthologues, 19 paralogues and is associated with 61 phenotypes. Biased expression in Liver (RPKM 134.1), Kidney (RPKM 127.) and 9 other tissues.

Summary

Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and nuclear receptor activity. Involved in several processes, including behavioral response to nicotine; negative regulation of cell growth involved in cardiac muscle cell development; and response to ethanol. Located in nucleus. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; fatty liver disease; hydrocephalus; and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppara Products (1)

mRNA Protein Name
NM_013196.2 NP_037328.1 peroxisome proliferator-activated receptor alpha

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
15661831 RGD
enables MDM2/MDM4 family protein binding IPI
IPI: Inferred from physical interaction
19103650 RGD
enables NFAT protein binding IPI
IPI: Inferred from physical interaction
22198280 RGD
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
28821620 RGD
enables nuclear receptor activity IMP
IMP: Inferred from mutant phenotype
12189208 RGD
enables phosphatase binding IPI
IPI: Inferred from physical interaction
8910358 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15051727 RGD
enables protein domain specific binding IDA
IDA: Inferred from direct assay
12189208 RGD
enables protein-containing complex binding IMP
IMP: Inferred from mutant phenotype
20132223 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
12189208 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16280383 RGD
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
22464285 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in behavioral response to nicotine IDA
IDA: Inferred from direct assay
20801430 RGD
involved in cellular response to fructose stimulus IEP
IEP: Inferred from expression pattern
11934685 RGD
involved in fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
12600885 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
15754086 RGD
involved in lipoprotein metabolic process IMP
IMP: Inferred from mutant phenotype
15537571 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
15967866 RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
22198280 RGD
involved in nitric oxide metabolic process IEP
IEP: Inferred from expression pattern
31489946 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12189208 RGD
involved in regulation of lipid storage IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
15292030 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
33310031 RGD
involved in response to insulin IMP
IMP: Inferred from mutant phenotype
16183630 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
33310031 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27939985 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ppara Protein Structure

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (237 - 320)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (337 - 603)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 605 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor alpha

  • PPAR-alpha

  • nuclear receptor subfamily 1 group C member 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-14728 Aleglitazar Agonist 99.74% Phase 3

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10919 PPARA Human Pre-designed siRNA Set A / Unkown
HY-RS10920 Ppara Mouse Pre-designed siRNA Set A / Unkown
HY-121579 L-764406 Agonist / Unkown
HY-RS10921 Ppara Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppara NCBI NCBI:5465