PPARA - peroxisome proliferator activated receptor alpha Gene

Also Known as PPAR; NR1C1; hPPAR; PPARalpha; PPAR-alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5465

About PPARA

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:46,150,526-46,243,756 (from NCBI)

This gene has 11 transcripts (splice variants), 455 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 12.0), heart (RPKM 8.1) and 24 other tissues.

Summary

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in Plants and Animals that contain Enzymes for respiration and for Cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

PPARA Products (28)

mRNA	Protein	Name
XM_011530239.3	XP_011528541.1	peroxisome proliferator-activated receptor alpha isoform X1
NM_001393941.1	NP_001380870.1	peroxisome proliferator-activated receptor alpha isoform 1
NM_001393943.1	NP_001380872.1	peroxisome proliferator-activated receptor alpha isoform 1
XM_011530240.3	XP_011528542.1	peroxisome proliferator-activated receptor alpha isoform X1
NM_001362872.2	NP_001349801.1	peroxisome proliferator-activated receptor alpha isoform 1
XM_047441428.1	XP_047297384.1	peroxisome proliferator-activated receptor alpha isoform X4
NM_001001929.3	NP_001001929.1	peroxisome proliferator-activated receptor alpha isoform 1
XM_047441421.1	XP_047297377.1	peroxisome proliferator-activated receptor alpha isoform X1
NM_005036.6	NP_005027.2	peroxisome proliferator-activated receptor alpha isoform 1
XM_047441427.1	XP_047297383.1	peroxisome proliferator-activated receptor alpha isoform X3
XM_047441430.1	XP_047297386.1	peroxisome proliferator-activated receptor alpha isoform X6
NM_001393945.1	NP_001380874.1	peroxisome proliferator-activated receptor alpha isoform 1
NM_032644.3
XM_047441429.1	XP_047297385.1	peroxisome proliferator-activated receptor alpha isoform X5
XM_047441422.1	XP_047297378.1	peroxisome proliferator-activated receptor alpha isoform X1
NM_001362873.3	NP_001349802.1	peroxisome proliferator-activated receptor alpha isoform 1
NM_001393942.1	NP_001380871.1	peroxisome proliferator-activated receptor alpha isoform 1
XM_017028839.2	XP_016884328.1	peroxisome proliferator-activated receptor alpha isoform X2
XM_047441424.1	XP_047297380.1	peroxisome proliferator-activated receptor alpha isoform X1
NM_001393947.1	NP_001380876.1	peroxisome proliferator-activated receptor alpha isoform 3
XM_047441426.1	XP_047297382.1	peroxisome proliferator-activated receptor alpha isoform X1
XM_047441420.1	XP_047297376.1	peroxisome proliferator-activated receptor alpha isoform X1
NM_001393946.1	NP_001380875.1	peroxisome proliferator-activated receptor alpha isoform 2
XM_047441425.1	XP_047297381.1	peroxisome proliferator-activated receptor alpha isoform X1
NM_001001930.2
NM_001001928.4	NP_001001928.1	peroxisome proliferator-activated receptor alpha isoform 1
XM_047441423.1	XP_047297379.1	peroxisome proliferator-activated receptor alpha isoform X1
NM_001393944.1	NP_001380873.1	peroxisome proliferator-activated receptor alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	26983400	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9748239	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19955185	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9748239	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9748239	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19955185	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	12955147	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	12955147	GOA
enables nuclear steroid receptor activity	IDA IDA: Inferred from direct assay	19955185	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9653119	GOA
enables ubiquitin conjugating enzyme binding	IPI IPI: Inferred from physical interaction	19955185	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cholesterol storage	IDA IDA: Inferred from direct assay	19114110	GOA
acts upstream of negative regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	31574452	GOA
involved in negative regulation of glycolytic process	IDA IDA: Inferred from direct assay	19955185	GOA
acts upstream of negative regulation of hepatocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	31574452	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	21636785	GOA
involved in negative regulation of leukocyte cell-cell adhesion	IDA IDA: Inferred from direct assay	21636785	GOA
involved in negative regulation of macrophage derived foam cell differentiation	IDA IDA: Inferred from direct assay	19114110	GOA
involved in negative regulation of miRNA transcription	IDA IDA: Inferred from direct assay	21636785	GOA
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	31574452	GOA
acts upstream of negative regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	31574452	GOA
involved in negative regulation of sequestering of triglyceride	IDA IDA: Inferred from direct assay	12700342	GOA
acts upstream of negative regulation of signaling receptor activity	IDA IDA: Inferred from direct assay	12700342	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9748239	GOA
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	31611175	GOA
acts upstream of positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	31574452	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12955147	GOA
involved in positive regulation of lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	25592151	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9748239	GOA
acts upstream of or within positive regulation of transformation of host cell by virus	IMP IMP: Inferred from mutant phenotype	22479552	GOA
involved in regulation of cellular ketone metabolic process	IDA IDA: Inferred from direct assay	19955185	GOA
involved in regulation of fatty acid metabolic process	IDA IDA: Inferred from direct assay	19955185	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	24639097	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPARA Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
468 a.a.

Protein Preferred Names	Protein Names
peroxisome proliferator-activated receptor alpha	nuclear receptor subfamily 1 group C member 1 peroxisome proliferative activated receptor, alpha

PPARA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPARA	Q07869	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	PPARA	Q07869	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	PPARA	Q07869	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	PPARA	Q07869	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	PPARA	Q07869	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	PPARA	Q07869	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	PPARA	Q07869	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	PPARA	Q07869	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	PPARA	Q07869	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	PPARA	Q07869	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	PPARA	Q07869	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	PPARA	Q07869	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	PPARA	Q07869	NCOR1	Homo sapiens	O75376	Anti Tag CoIP	19955185
Intra	PPARA	Q07869	NCOR1	Homo sapiens	O75376	Alpha-Screen	21775429
Intra	PPARA	Q07869	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	PPARA	Q07869	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	PPARA	Q07869	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	PPARA	Q07869	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	PPARA	Q07869	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	PPARA	Q07869	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	PPARA	Q07869	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	PPARA	Q07869	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	PPARA	Q07869	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	PPARA	Q07869	GRB2	Homo sapiens	P62993	Validated Y2H	25814554
Intra	PPARA	Q07869	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	PPARA	Q07869	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	PPARA	Q07869	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	PPARA	Q07869	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	PPARA	Q07869	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	PPARA	Q07869	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	PPARA	Q07869	CCK	Homo sapiens	P06307	Validated Y2H	32814053
Intra	PPARA	Q07869	CCK	Homo sapiens	P06307	Y2H Pooling	32814053
Intra	PPARA	Q07869	CCK	Homo sapiens	P06307	Y2H Array	32814053
Intra	PPARA	Q07869	RAD23A	Homo sapiens	P54725	Y2H Array	32814053
Intra	PPARA	Q07869	RAD23A	Homo sapiens	P54725	Y2H Pooling	32814053
Intra	PPARA	Q07869	RAD23A	Homo sapiens	P54725	Validated Y2H	32814053
Intra	PPARA	Q07869	NR1H3	Homo sapiens	Q13133	CD	24713062
Intra	PPARA	Q07869	NR1H3	Homo sapiens	Q13133	Anti Bait CoIP	24713062
Intra	PPARA	Q07869	NR1H3	Homo sapiens	Q13133	Fluorescence	24713062
Intra	PPARA	Q07869	CHD9	Homo sapiens	Q3L8U1-3	Pull Down	16554032

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPARA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7996	PPAR alpha Protein, Human (His)	Q07869-1 (D202-Y468)	≥ 90%, as determined by reducing SDS-PAGE.

PPARA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80871	PPAR alpha Antibody	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86449	PPAR alpha Antibody (YA6141)	WB, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Psoriasis
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases Cardiovascular Disease
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Disease, Susceptibility To Coronary Artery Anomaly Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Hypoalphalipoproteinemia
Lysosomal Storage Disease	Lysosomal Storage Diseases Disorder Of Lysosomal Enzyme Inborn Lysosomal Enzyme Disorder Lysosomal Storage Metabolism Disorder Lysosomal Storage Disorder
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Myopathy	Muscular Diseases Myopathies
Overnutrition
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Adult Syndrome	Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome Acro Dermato Ungual Lacrimal Tooth Syndrome Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome Adult
Hypertensive Heart Disease
Glucose Metabolism Disease	Glucose Metabolism Disorders Disorder Of Glucose Metabolism
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Diabetes Mellitus	Diabetes
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Lipid Storage Disease	Lipoidosis Inborn Lipid Storage Disorder Lipoid Storage Diseas Lipid Storage Diseases Lipidoses
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Abdominal Obesity-Metabolic Syndrome 1	Metabolic Syndrome X Metabolic Syndrome AOMS1 Dysmetabolic Syndrome X Metabolic Disease Abdominal Obesity Metabolic Syndrome
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Liposarcoma	Lipomatous Cancer
Headache	Headache Disorder
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Adrenoleukodystrophy	X-Linked Adrenoleukodystrophy ALD Siemerling-Creutzfeldt Disease X-Ald X-Linked Cerebral Adrenoleukodystrophy Bronze Schilder Disease Melanodermic Leukodystrophy Addison Disease And Cerebral Sclerosis Adrenomyeloneuropathy, Adult Diffuse Sclerosis X-Cald Adrenomyeloneuropathy Encephalitis Periaxialis Concentrica Encephalitis Periaxialis, Schilder'S Sudanophilic Cerebral Sclerosis Ald Childhood Cerebral Form Adrenoleukodystrophy X-Linked Cerebral Form Adrenoleukodystrophy Childhood Cerebral Form Childhood Cerebral Ald Schilder Disease X-Linked Ald Adrenoleukodystrophy, X-Linked Amn Diffuse Cerebral Sclerosis Of Schilder Systemic Scleroderma Balo'S Concentric Sclerosis Ald - [Adrenoleukodystrophy] Addison-Schilder
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipemia Hyperlipidemias Hyperlipidemia
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Chanarin-Dorfman Syndrome	Neutral Lipid Storage Disease CDS Neutral Lipid Storage Disease With Ichthyosis Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation Triglyceride Storage Disease With Ichthyosis Nlsdi Ichthyotic Neutral Lipid Storage Disease Dcs Chanarin-Dorfman Disease Ichthyosiform Erythroderma With Leukocyte Vacuolation Dorfman-Chanarin Syndrome Lipidosis With Triglyceride Storage Disease Disorder Of Cornification 12 Dorfman Chanarin Syndrome Neutral Lipid Storage Disease With Ichthyotic Dorfman-Chanarin Disease
Acute Tympanitis	Acute Myringitis
Tularemia	Francisella Tularensis Infection Deerfly Fever Lemming Fever Ohara Disease Pahvant Valley Plague Rabbit Fever Yatobyo
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Liver Benign Neoplasm	Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Schizophrenia 16	SCZD16 Schizophrenia Susceptibility Locus, Chromosome 7q36.3-Related Chromosome 7q36.3 Duplication Syndrome, 362-Kb
Non-Alcoholic Steatohepatitis	Nonalcoholic Steatohepatitis Nash Nash - [Non-Alcoholic Steatohepatitis] Non-Alcoholic Steatohepatosis
Alzheimer Disease 11	Ad11 Alzheimer'S Disease 11 Alzheimer Disease, Familial, 11 Alzheimer Disease-11 Alzheimer'S Disease 11, Late Onset
Carbohydrate Metabolic Disorder	Inborn Errors Of Carbohydrate Metabolism Disorder Of Carbohydrate Metabolism Carbohydrate Metabolism, Inborn Errors Disorder Of Carbohydrate Transport And Metabolism Inborn Carbohydrate Metabolism Disorder Inborn Carbohydrate Metabolic Disorder Carbohydrate Metabolism Disorder Carbohydrate Metabolism Disorders Disorders Of Carbohydrate Metabolism Congenital Disorders Of Carbohydrate Metabolism Inherited Disorders Of Carbohydrate Metabolism
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction Leptin
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2	Abdominal Obesity-Metabolic Syndrome Abdominal Obesity Metabolic Syndrome Metabolic Syndrome X Aoms2 Aoms1
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Gilbert Syndrome	Gilbert Disease Gilbert'S Disease Gilbert'S Syndrome Cholemia, Familial Meulengracht Syndrome Gilbert Syndrome, Susceptibility To Hyperbilirubinemia, Gilbert Type Hblrg Hyperbilirubinemia, Arias Type Hyperbilirubinemia I Constitutional Hyperbilirubinemia Gilbert-Meulengracht Syndrome Hereditary Nonhemolytic Jaundice Hyperbilirubinemia Arias Type Hyperbilirubinemia Type 1 Constitutional Liver Dysfunction Familial Nonhemolytic Jaundice Gilbert-Lereboullet Syndrome Hyperbilirubinemia 1 Unconjugated Benign Bilirubinemia GILBS Gilberts Syndrome Familial Nonhaemolytic Jaundice Constitutional Hyperbilirubinaemia Hereditary Nonhaemolytic Bilirubinaemia Familial Nonhaemolytic Bilirubinaemia Idiopathic Hyperbilirubinaemia Icterus Intermittens Juvenilis Chronic Intermittent Juvenile Jaundice Low-Grade Chronic Hyperbilirubinaemia Syndrome Benign Unconjugated Bilirubinaemia Syndrome Hereditary Nonhaemolytic Jaundice Idiopathic Unconjugated Hyperbilirubinaemia Gilbert--Lereboullet Syndrome Constitutional Hepatic Dysfunction Meulengracht Icterus Cholaemia Familiaris Simplex Familial Cholaemia Congenital Familial Cholaemia Physiologic Cholaemia Hyperbilirubinaemia Type 1 Gilbert Cholaemia
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy, Hypertrophic, Familial Familial Hypertrophic Cardiomyopathy Cardiomyopathy Hypertrophic Obstructive Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Familial Partial Lipodystrophy	Lipodystrophy, Familial Partial Fpld Kobberling-Dunnigan Syndrome Dunnigan Syndrome Koberling-Dunnigan Syndrome Dunnigan-Kobberling Syndrome Fpl Familial Partial Lipodystrophy, Type 2
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Platelet Glycoprotein Iv Deficiency	Platelet-Type Bleeding Disorder 10 Bdplt10 Cd36 Deficiency Bleeding Disorder, Platelet-Type, 10 PG4D Bleeding Disorder Platelet-Type 10 Deficiency, Platelet Glycoprotein Iv
Inherited Metabolic Disorder	Inborn Errors Of Metabolism Inborn Metabolism Disorder Metabolic Hereditary Disorder Inborn Error Of Metabolism Inborn Metabolic Disorder Metabolism, Inborn Errors
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Hepatocellular Adenoma	Adenoma Hepatocellular
Proteasome-Associated Autoinflammatory Syndrome 1	Jmp Syndrome Nakajo-Nishimura Syndrome Nkjo Autoinflammation, Lipodystrophy, And Dermatosis Syndrome Proteasome-Associated Autoinflammatory Syndrome 1 And Digenic Forms Nakajo Syndrome PRAAS1 Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature Syndrome Candle Joint Contractures, Muscular Atrophy, Microcytic Anemia, And Panniculitis-Induced Lipodystrophy Aldd Joint Contractures - Muscle Atrophy - Microcytic Anemia - Panniculitis-Induced Lipodystrophy Nakajo Nishimura Syndrome Amyotrophy Fat Tissue Anomaly Japanese Autoinflammatory Syndrome With Lipodystrophy Jasl Joint Contractures Muscular Atrophy Microcytic Anemia And Panniculitis-Induced Lipodystrophy Nns Nodular Erythema With Digital Changes Secondary Hypertrophic Osteoperiostosis With Pernio Inflammation
Cone-Rod Dystrophy 17	CORD17
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Peroxisome Biogenesis Disorder Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Hepatoblastoma
Hyperinsulinism	Hyperinsulinemia
Choline Deficiency Disease	Choline Deficiency
Arteriosclerosis	Arteriosclerotic Vascular Disease
Acquired Metabolic Disease
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Alcoholic Hepatitis	Acute Alcoholic Hepatitis Acute Alcoholic Liver Disease Hepatitis, Alcoholic Hepatitis Alcoholic Ah - [Alcoholic Hepatitis] Ethanol Hepatitis
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Tangier Disease	Analphalipoproteinemia High Density Lipoprotein Deficiency, Tangier Type TGD High Density Lipoprotein Deficiency, Type 1 Hdldt1 Familial High Density Lipoprotein Deficiency A-Alphalipoprotein Neuropathy Alpha High Density Lipoprotein Deficiency Disease Cholesterol Thesaurismosis Familial High Density Lipoprotein Deficiency Disease Hdl Lipoprotein Deficiency Disease Tangier Disease Neuropathy Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency 1 Primary Hypoalphalipoproteinemia 1 Analphalipo-Proteinemia Familial Hypoalphalipo-Proteinemia Familial Hypoalphalipoproteinemia Lipoprotein Deficiency Disease, Hdl, Familial Tangier Hereditary Neuropathy Atp-Binding Cassette Transporter A1 Deficiency Hdld1 High Density Lipoprotein Deficiency 1 Tangier Disease, Variant Hypoalphalipoproteinemia, Familial Familial Hdl Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14728	Aleglitazar	Agonist	99.74%	Phase 3

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10919	PPARA Human Pre-designed siRNA Set A		/	Unkown
HY-RS10920	Ppara Mouse Pre-designed siRNA Set A		/	Unkown
HY-121579	L-764406	Agonist	/	Unkown
HY-RS10921	Ppara Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPARA	VGNC	VGNC:33181
Felis catus	PPARA	VGNC	VGNC:68974
Mus musculus	PPARA	MGD	MGI:104740
Macaca mulatta	PPARA	VGNC	VGNC:76227
Rattus norvegicus	PPARA	RGD	RGD:3369
Canis familiaris	PPARA	VGNC	VGNC:44834
Others	PPARA	NCBI