GPR17 antagonist 1
Based on 1 Customer Validation
GPR17 antagonist 1 (compound 978) is a GPR17 antagonist. GPR17 antagonist 1 can be used in the study of diabetes and obesity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.95%
- CAS. Nr.: 1574405-61-0
- Formel: C21H21ClN2O3
- Molecular Weight:384.86
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Chemical Information
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CAS. Nr. 1574405-61-0
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Appearance Solid
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Molecular Weight 384.86
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Formel C21H21ClN2O3
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Color White to off-white
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SMILES
O=C(C1=CC=C(C(OC)=C1)OC)NC2C3=C(CCC2)C4=C(C(Cl)=CC=C4)N3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (259.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5983 mL | 12.9917 mL | 25.9835 mL | 64.9587 mL |
| 5 mM | 0.5197 mL | 2.5983 mL | 5.1967 mL | 12.9917 mL | |
| 10 mM | 0.2598 mL | 1.2992 mL | 2.5983 mL | 6.4959 mL | |
| 15 mM | 0.1732 mL | 0.8661 mL | 1.7322 mL | 4.3306 mL | |
| 20 mM | 0.1299 mL | 0.6496 mL | 1.2992 mL | 3.2479 mL | |
| 25 mM | 0.1039 mL | 0.5197 mL | 1.0393 mL | 2.5983 mL | |
| 30 mM | 0.0866 mL | 0.4331 mL | 0.8661 mL | 2.1653 mL | |
| 40 mM | 0.0650 mL | 0.3248 mL | 0.6496 mL | 1.6240 mL | |
| 50 mM | 0.0520 mL | 0.2598 mL | 0.5197 mL | 1.2992 mL | |
| 60 mM | 0.0433 mL | 0.2165 mL | 0.4331 mL | 1.0826 mL | |
| 80 mM | 0.0325 mL | 0.1624 mL | 0.3248 mL | 0.8120 mL | |
| 100 mM | 0.0260 mL | 0.1299 mL | 0.2598 mL | 0.6496 mL |
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