Janagliflozin
Janagliflozin is orally active and highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor (IC50=0.0058 μM for SGLT2 and 4.802 μM for SGLT1). Janagliflozin inhibits SGLT2 in the proximal renal tubules, reducing glucose reabsorption and promoting urinary glucose excretion (UGE) to lower blood glucose levels. Janagliflozin is promising for research of type 2 diabetes mellitus.
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- CAS. Nr.: 1800115-22-3
- Formel: C25H29ClO6
- Molecular Weight:460.95
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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SGLT1 4.802 μM (IC50) |
SGLT2 0.0058 μM (IC50) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1800115-22-3
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Molecular Weight 460.95
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Formel C25H29ClO6
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SMILES
[H][C@](C1)(C2)[C@@]1([H])C[C@H]2OC3=CC=C(C=C3)CC4=CC([C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)=CC=C4Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Song L, et al. A Model-Informed Approach to Accelerate the Clinical Development of Janagliflozin, an Innovative SGLT2 Inhibitor. Clin Pharmacokinet. 2023 Mar;62(3):505-518. [Content Brief]
[2]. Zhao H, et al. Prediction of janagliflozin pharmacokinetics in type 2 diabetes mellitus patients with liver cirrhosis or renal impairment using a physiologically based pharmacokinetic model. Eur J Pharm Sci. 2022 Dec 1;179:106298. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Janagliflozin Related Classifications
HY-178734 Related Classifications
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