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Art. -Nr.: HY-P11285

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LAGIPRA peptide

(Synonyms: Long acting GIPRA-1)

LAGIPRA peptide is a long-acting GIP1R agonist. LAGIPRA peptide enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. LAGIPRA peptide has the potential for the research of type 2 diabetes.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₆₄H₄₀₆N₆₄O₇₈S
Molecular Weight:5756.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

LAGIPRA peptide Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

LAGIPRA peptide (1000 nmol/kg; sc) reduces hyperglycemia in intraperitoneal glucose tolerance test experiments in Glp-1r^-/- mice, but had no effect in Gipr-deficient (Gipr^-/-) animals^[1].
LAGIPRA peptide (300 nmol/kg; sc; once a day for 14 days) shows a small (4% reduction) effect on body weight and transient reduction (during the first 24-48 hours) in food intake, decreases fasting glucose and insulin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male IR mice (onsisting of 60% fat, 20% carbohydrate, and 20% protein caloric content D12492; Research Diets)^[1]
Dosage:

300 nmol/kg
Administration:

SC; once a day for 14 days
Result:

Showed a small (4% reduction) effect on body weight and transient reduction (during the first 24-48 hours) in food intake, decreases fasting glucose and insulin.

Chemical Information

Molecular Weight 5756.50
Formel C₂₆₄H₄₀₆N₆₄O₇₈S
Synonyms

Long acting GIPRA-1
Sequence

Tyr-{Aib}-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-{Lys(AEEA-AEEA-γGlu-C20 diacid)}-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln
Sequence Shortening

Y-{Aib}-EGTFISDYSIAMDK-{Lys(AEEA-AEEA-γGlu-C20 diacid)}-HQQDFVNWLLAQKGKKNDWKHNITQ
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Samms RJ, et al. GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice. J Clin Invest. 2021 Jun 15;131(12):e146353. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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