mIDH1-IN-1
mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research.
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- CAS. Nr.: 2757155-96-5
- Formel: C25H27N3O5
- Molecular Weight:449.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
IC50: 961.5 ± 25.3 nM (IDH1R132H); EC50: 208.6 ± 8.0 nM (2-HG)[1]
Chemical Information
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CAS. Nr. 2757155-96-5
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Molecular Weight 449.50
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Formel C25H27N3O5
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SMILES
C#CC(N(C(C1=C(C=C(C=C1)OC)C)C(NC2CCCCC2)=O)C3=CC=C(C=C3)[N+]([O-])=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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