100 Results for "

Norepinephrine transporter inhibitor

" in MedChemExpress (MCE) Product Catalog:
Products (100)

100 Results for "Norepinephrine transporter inhibitor" in MCE Product Catalog:

AR-13324 analog mesylate
AR-13324 analog mesylate
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Art. -Nr.: HY-19346
CAS. Nr.: 2095432-73-6
Target:  

ROCK

Forschungsgebiete:  

Others

AR-13324 analog mesylate is an analog of AR-13324. AR-13324 is an ROCK and norepinephrine transporter (NET) inhibitor .
WAY-260022
WAY-260022
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Art. -Nr.: HY-10427
CAS. Nr.: 850692-43-2
Synonyms: NRI-022
Target:  

Histone Methyltransferase

Forschungsgebiete:  

Neurological Disease

WAY-260022 is a selective norepinephrine reuptake inhibitor with potent inhibitory activity on norepinephrine reuptake. WAY-260022 exhibits excellent selectivity in inhibiting serotonin and dopamine transporters. WAY-260022 also showed oral efficacy in a rat model of thermoregulatory dysfunction .
SRI-29574
SRI-29574
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Art. -Nr.: HY-126158
CAS. Nr.: 1928712-46-2
Target:  

Dopamine Transporter Serotonin Transporter

Forschungsgebiete:  

Neurological Disease

SRI-29574 is an allosteric modulator of the dopamine transporter (DAT). SRI-29574 partially inhibits the uptake of the DAT (IC50=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET). SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT .
Milnacipran-d5 hydrochloride
Milnacipran-d5 hydrochloride
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Art. -Nr.: HY-B0168AS
CAS. Nr.: 2750534-79-1
Milnacipran-d5 hydrochloride is deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
BMS-505130 fumarate
BMS-505130 fumarate
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Art. -Nr.: HY-105297
CAS. Nr.: 859230-84-5
Target:  

5-HT Receptor

Forschungsgebiete:  

Neurological Disease

BMS-505130 fumarate is a potent, selective and orally active serotonin transport inhibitor with a Ki for binding to the serotonin transporter of 0.18 nM (Ki for norepinephrine and dopamine transporters of 4.6 and 2.1 μM, respectively). BMS-505130 fumarate can be used for the research of neurological disease, such as depression .
Milnacipran hydrochloride (Standard)
Milnacipran hydrochloride (Standard)
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Art. -Nr.: HY-B0168AR
CAS. Nr.: 101152-94-7
Target:  

Reference Standards Serotonin Transporter PERK

Forschungsgebiete:  

Neurological Disease

Milnacipran (hydrochloride) (Standard) is the analytical standard of Milnacipran hydrochloride (HY-B0168A). This product is intended for research and analytical applications. Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
Desmethyl Sibutramine hydrochloride (Standard)
Desmethyl Sibutramine hydrochloride (Standard)
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Art. -Nr.: HY-135615AR
CAS. Nr.: 84467-94-7
Synonyms: N-Desmethylsibutramine hydrochloride (Standard)
Target:  

Reference Standards Serotonin Transporter

Forschungsgebiete:  

Neurological Disease Metabolic Disease

Desmethyl Sibutramine (hydrochloride) (Standard) is the analytical standard of Desmethyl Sibutramine (hydrochloride). This product is intended for research and analytical applications. Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant .
D595
D595
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Art. -Nr.: HY-117542
CAS. Nr.: 16740-29-7
Target:  

Histone Methyltransferase

Forschungsgebiete:  

Neurological Disease

D595 is a phenylethylamine calcium channel blocker with potent negative inotropic activity. D595 has shown significant efficacy in its corresponding pharmacological studies, especially in inhibiting the uptake of monoamine neurotransmitters. D595 has high affinity in binding to the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Structural adjustments of D595, especially changes in the hydroxyl stereochemistry, significantly affect its interaction with the transporters, showing a specific preference for stereoisomers .
Clovoxamine
Clovoxamine
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Art. -Nr.: HY-129985
CAS. Nr.: 54739-19-4
Synonyms: DU23811
Target:  

Serotonin Transporter 5-HT Receptor

Forschungsgebiete:  

Neurological Disease

Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant .
JNJ-7925476
JNJ-7925476
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Art. -Nr.: HY-116062A
CAS. Nr.: 129540-12-1
Target:  

Histone Methyltransferase

Forschungsgebiete:  

Neurological Disease

JNJ-7925476 is a triple reuptake inhibitor that selectively and potently inhibits the activity of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). JNJ-7925476 is rapidly absorbed into the blood and its concentration in the brain is 7-fold higher than that in plasma. The occupancy ED(50) values of JNJ-7925476 for SERT, NET, and DAT in the rat brain are 0.18, 0.09, and 2.4 mg/kg, respectively. JNJ-7925476 rapidly induces a significant increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex in a dose-dependent manner. JNJ-7925476 exhibits potent antidepressant-like activity in the mouse tail suspension test. These results suggest that JNJ-7925476 has in vivo efficacy in biochemical and behavioral models of depression .
Escitalopram (Standard)
Escitalopram (Standard)
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Art. -Nr.: HY-14258R
CAS. Nr.: 128196-01-0
Synonyms: (S)-Citalopram (Standard); (S)-(+)-Citalopram (Standard)
Category:  

Natural Products Endogenous metabolite

Target:  

Serotonin Transporter Reference Standards

Escitalopram (Standard) is the analytical standard of Escitalopram. This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .
Levomilnacipran-d10 hydrochloride
Levomilnacipran-d10 hydrochloride
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Art. -Nr.: HY-14794AS
CAS. Nr.: 2747914-23-2
Synonyms: (1S,2R)-Milnacipran-d10 hydrochloride; F2695-d10 hydrochloride
Levomilnacipran-d10 ((1S,2R)-Milnacipran-d10) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .
Levomilnacipran-d5 hydrochloride
Levomilnacipran-d5 hydrochloride
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Art. -Nr.: HY-B0168BS
Synonyms: (1S,2R)-Milnacipran-d5 hydrochloride; F-2695-d5 hydrochloride
Levomilnacipran-d5 ((1S,2R)-Milnacipran-d5) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .
Levocarnitine propionate hydrochloride (Standard)
Levocarnitine propionate hydrochloride (Standard)
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Art. -Nr.: HY-B0932R
CAS. Nr.: 119793-66-7
Synonyms: L-Propionylcarnitine chloride (Standard); ST-261 (Standard)
Target:  

Integrin NADPH Oxidase Reference Standards Others

Forschungsgebiete:  

Others

Adrenalone (hydrochloride) (Standard) is the analytical standard of Adrenalone (hydrochloride). This product is intended for research and analytical applications. Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM .
Adrenalone hydrochloride (Standard)
Adrenalone hydrochloride (Standard)
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Art. -Nr.: HY-B1308R
CAS. Nr.: 62-13-5
Target:  

Reference Standards Adrenergic Receptor

Forschungsgebiete:  

Cardiovascular Disease Endocrinology

Adrenalone (hydrochloride) (Standard) is the analytical standard of Adrenalone (hydrochloride). This product is intended for research and analytical applications. Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM .
Desvenlafaxine succinate
Desvenlafaxine succinate
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Art. -Nr.: HY-16170
CAS. Nr.: 448904-47-0
Synonyms: O-Desmethylvenlafaxine succinate; Wy-45233 succinate
Target:  

Serotonin Transporter

Forschungsgebiete:  

Neurological Disease Metabolic Disease

Desvenlafaxine succinate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate (DVS) shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .
Atomoxetine hydrochloride (Standard)
Atomoxetine hydrochloride (Standard)
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Art. -Nr.: HY-17385R
CAS. Nr.: 82248-59-7
Synonyms: Tomoxetine hydrochloride (Standard); (R)-Tomoxetine hydrochloride (Standard); LY 139603 (Standard)
Target:  

Reference Standards Adrenergic Receptor Serotonin Transporter Sodium Channel

Forschungsgebiete:  

Neurological Disease Cancer

Atomoxetine (hydrochloride) (Standard) is the analytical standard of Atomoxetine (hydrochloride). This product is intended for research and analytical applications. Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .
Desipramine-d4
Desipramine-d4
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Art. -Nr.: HY-B1272AS
CAS. Nr.: 61361-34-0
Desipramine-d4 is the deuterium labeled Desipramine (HY-B1272A). Desipramine is a first-generation tricyclic antidepressant. Desipramine selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine can be used for the research of hepatocellular cancer, inflammation, and neurological diseases .
Desipramine-d3
Desipramine-d3
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Art. -Nr.: HY-B1272AS1
CAS. Nr.: 65100-49-4
Desipramine-d3 is the deuterium labeled Desipramine (HY-B1272A). Desipramine is a first-generation tricyclic antidepressant. Desipramine selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine can be used for the research of hepatocellular cancer, inflammation, and neurological diseases .
Desvenlafaxine-d10
Desvenlafaxine-d10
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Art. -Nr.: HY-B0602S3
CAS. Nr.: 1062607-49-1
Desvenlafaxine-d10 is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .
Assay Types