448904-47-0
Chemical Structure
Desvenlafaxine succinate
Synonym(s): O-Desmethylvenlafaxine succinate; Wy-45233 succinate
- CAS No.: 448904-47-0
- Formula:C20H31NO6
- Molecular Weight:381.46
IUPAC Name: 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate
InChIKey: ORUUBRMVQCKYHB-UHFFFAOYSA-N
SMILES: O=C(O)CCC(O)=O.OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1
Biological Activity: Desvenlafaxine succinate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate (DVS) shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].
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Desvenlafaxine succinate | Desvenlafaxine succinate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate (DVS) shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter. | |||||||||||||||||||||
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- [1]. Darlene C Deecher, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug;318(2):657-65. [Content Brief]
- [2]. Michael A Sopko Jr, et al. Desvenlafaxine: another "me too" drug? Ann Pharmacother. 2008 Oct;42(10):1439-46. [Content Brief]
Keywords
