54739-19-4
54739-19-4
Chemical Structure
Clovoxamine
Synonym(s): DU23811
- CAS No.: 54739-19-4
- Formula:C14H21ClN2O2
- Molecular Weight:284.78
IUPAC Name: (Z)-1-(4-chlorophenyl)-5-methoxypentan-1-one O-(2-aminoethyl) oxime
InChIKey: XXPVSQRPGBUFKM-VKAVYKQESA-N
SMILES: COCCCC/C(C1=CC=C(C=C1)Cl)=N/OCCN
Biological Activity: Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant[1][2][3].
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Clovoxamine | Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant. | |||||||||||||||||||||
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References
- [1]. Staroń J, et al. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. Eur J Med Chem. 2021 Aug 5;220:113533. [Content Brief]
- [2]. Saletu B, et al. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49(1-2):63-86. [Content Brief]
- [3]. de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183(2):203-11. [Content Brief]
Keywords
