GLS2 - glutaminase 2 Gene

Also Known as GA; GLS; LGA; hLGA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27165

About GLS2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,470,952-56,488,161 (from NCBI)

This gene has 17 transcripts (splice variants), 252 orthologues and 1 paralogue. Biased expression in liver (RPKM 39.1), brain (RPKM 4.2) and 2 other tissues.

Summary

The protein encoded by this gene is a mitochondrial phosphate-activated Glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in Other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

GLS2 Products (4)

mRNA Protein Name
NM_001280796.2 NP_001267725.1 glutaminase liver isoform, mitochondrial isoform 3
NM_001280797.2 NP_001267726.1 glutaminase liver isoform, mitochondrial isoform 4
NM_001280798.2 NP_001267727.1 glutaminase liver isoform, mitochondrial isoform 4
NM_013267.4 NP_037399.2 glutaminase liver isoform, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11163757 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
20351271 GOA
acts upstream of or within regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20351271 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
20351271 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLS2 Protein Structure

Glutaminase

Glutaminase: Glutaminase (177 - 463)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (490 - 575)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 602 a.a.
Protein Preferred Names Protein Names

glutaminase liver isoform, mitochondrial

  • L-glutamine amidohydrolase

GLS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GLS2 Q9UI32 XAF1 Homo sapiens Q6GPH4
Y2H Prey Pooling
32296183
Intra
GLS2 Q9UI32 XAF1 Homo sapiens Q6GPH4
Y2H Array
32296183
Intra
GLS2 Q9UI32 HIP1 Homo sapiens O00291
Anti Tag CoIP
33961781
Intra
GLS2 Q9UI32 HIP1 Homo sapiens O00291
Y2H Prey Pooling
32296183
Intra
GLS2 Q9UI32 HIP1 Homo sapiens O00291
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Juvenile Dermatitis Herpetiformis
Metabolic Acidosis
Sclerosing Keratitis

  • Sclerokeratitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-12248 Telaglenastat 99.82% Phase 2
HY-12248A Telaglenastat hydrochloride 98.03% Phase 2
HY-P2760 Glutaminase Control / Phase 2
HY-103671 IPN60090 Inhibitor 98.96% Phase 1
HY-103671A IPN60090 dihydrochloride Inhibitor 99.68% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151434 GLS1 Inhibitor-6 / Unkown
HY-RS05503 GLS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17808 Gls2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24276 Gls2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GLS2 VGNC VGNC:29420
Canis familiaris GLS2 VGNC VGNC:41277
Mus musculus GLS2 MGD MGI:2143539
Felis catus GLS2 VGNC VGNC:62595
Macaca mulatta GLS2 VGNC VGNC:73035
Rattus norvegicus GLS2 RGD RGD:620359
Others GLS2 NCBI