ATAD2 - ATPase family AAA domain containing 2 Gene

Also Known as ANCCA; CT137; PRO2000

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29028

About ATAD2

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:123,319,850-123,416,350 (from NCBI)

This gene has 8 transcripts (splice variants), 232 orthologues and 1 paralogue. Broad expression in testis (RPKM 15.3), bone marrow (RPKM 13.1) and 23 other tissues.

Summary

A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 Amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

ATAD2 Products (1)

mRNA Protein Name
NM_014109.4 NP_054828.2 ATPase family AAA domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
17998543 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17998543 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17998543 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
25593309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATAD2 Protein Structure

AAA

AAA: ATPase family associated with various cellular activities (AAA) (464 - 597)

Bromodomain

Bromodomain: Bromodomain (1004 - 1068)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1390 a.a.
Protein Preferred Names Protein Names

ATPase family AAA domain-containing protein 2

  • AAA nuclear coregulator cancer-associated protein

ATAD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATAD2 Q6PL18 ESR1 Homo sapiens P03372
Anti Bait CoIP
17998543
Intra
ATAD2 Q6PL18 ESR1 Homo sapiens P03372
Pull Down
17998543
Intra
ATAD2 Q6PL18 NCOA3 Homo sapiens Q9Y6Q9
Pull Down
17998543
Intra
ATAD2 Q6PL18 NCOA3 Homo sapiens Q9Y6Q9
Anti Bait CoIP
17998543
Cross: Cross-species interaction Intra: Intraspecies interaction

ATAD2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82049 ATAD2 Antibody (YA1794) WB, ICC/IF, FC Human

Related Diseases

Diseases Alias
Uterine Corpus Endometrial Carcinoma
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119254 BAY-850 Inhibitor 98.93% Unkown
HY-114204 GSK8814 Inhibitor 99.80% Unkown
HY-136521 AZ13824374 Inhibitor 99.22% Unkown
HY-119254A trans-BAY-850 Control 99.30% Unkown
HY-163108 ATAD2-IN-1 / Unkown
HY-P10326 Z-ATAD-FMK Inhibitor / Unkown
HY-RS01119 ATAD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01120 ATAD2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17197 Atad2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23649 Atad2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ATAD2 VGNC VGNC:59989
Mus musculus ATAD2 MGD MGI:1917722
Canis familiaris ATAD2 VGNC VGNC:38201
Rattus norvegicus ATAD2 RGD RGD:1304849
Bos taurus ATAD2 VGNC VGNC:26233
Macaca mulatta ATAD2 VGNC VGNC:70154
Others ATAD2 NCBI