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  2. Epigenetic Reader Domain
  3. GSK8814

GSK8814 

Cat. No.: HY-114204
Handling Instructions

GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1.

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GSK8814 Chemical Structure

GSK8814 Chemical Structure

CAS No. : 1997369-78-4

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Description

GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1[1].

IC50 & Target

ATAD2

8.9 (pKi)

ATAD2

8 nM (Ki)

BRD4 BD1

4.6 (pIC50)

Molecular Weight

527.61

Formula

C₂₈H₃₅F₂N₅O₃

CAS No.

1997369-78-4

SMILES

O=C1NC2=C(N[[email protected]]3[[email protected]](OCC4CCC(F)(F)CC4)CNC[[email protected]@H]3OC)N=CC(C5=CC(C)=CN=C5)=C2C=C1C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GSK8814GSK 8814GSK-8814Epigenetic Reader DomainprobeselectivecanceranalogInhibitorinhibitorinhibit

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GSK8814
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