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  3. GSK8814

GSK8814 

Cat. No.: HY-114204 Purity: ≥99.0%
COA Handling Instructions

GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1.

For research use only. We do not sell to patients.

GSK8814 Chemical Structure

GSK8814 Chemical Structure

CAS No. : 1997369-78-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 506 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 506 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 460 In-stock
Estimated Time of Arrival: December 31
10 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1[1].

IC50 & Target

ATAD2

8.9 (pKi)

ATAD2

8 nM (Ki)

BRD4 BD1

4.6 (pIC50)

Molecular Weight

527.61

Formula

C28H35F2N5O3

CAS No.
SMILES

O=C1NC2=C(N[[email protected]]3[[email protected]](OCC4CCC(F)(F)CC4)CNC[[email protected]@H]3OC)N=CC(C5=CC(C)=CN=C5)=C2C=C1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (189.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8953 mL 9.4767 mL 18.9534 mL
5 mM 0.3791 mL 1.8953 mL 3.7907 mL
10 mM 0.1895 mL 0.9477 mL 1.8953 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥99.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
GSK8814
Cat. No.:
HY-114204
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