BEGAIN - brain enriched guanylate kinase associated Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57596

About BEGAIN

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:100,537,147-100,587,417 (from NCBI)

This gene has 11 transcripts (splice variants) and 116 orthologues. Broad expression in brain (RPKM 1.4), adrenal (RPKM 0.4) and 14 other tissues.

Summary

Predicted to be involved in regulation of postsynaptic neurotransmitter receptor activity. Predicted to act upstream of or within evoked excitatory postsynaptic potential. Predicted to be located in dendrite; nucleus; and presynapse. Predicted to be active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]

BEGAIN Products (25)

mRNA Protein Name
NM_001159531.2 NP_001153003.1 brain-enriched guanylate kinase-associated protein isoform 1
NM_001385082.1 NP_001372011.1 brain-enriched guanylate kinase-associated protein isoform 1
NM_001385083.1 NP_001372012.1 brain-enriched guanylate kinase-associated protein isoform 1
NM_001385084.1 NP_001372013.1 brain-enriched guanylate kinase-associated protein isoform 1
NM_001385085.1 NP_001372014.1 brain-enriched guanylate kinase-associated protein isoform 2
NM_001385086.1 NP_001372015.1 brain-enriched guanylate kinase-associated protein isoform 3
NM_001385087.1 NP_001372016.1 brain-enriched guanylate kinase-associated protein isoform 4
NM_001385088.1 NP_001372017.1 brain-enriched guanylate kinase-associated protein isoform 5
NM_001385089.1 NP_001372018.1 brain-enriched guanylate kinase-associated protein isoform 6
NM_001385090.1 NP_001372019.1 brain-enriched guanylate kinase-associated protein isoform 7
NM_001385091.1 NP_001372020.1 brain-enriched guanylate kinase-associated protein isoform 8
NM_001385092.1 NP_001372021.1 brain-enriched guanylate kinase-associated protein isoform 9
NM_001385093.1 NP_001372022.1 brain-enriched guanylate kinase-associated protein isoform 10
NM_001385094.1 NP_001372023.1 brain-enriched guanylate kinase-associated protein isoform 11
NM_001385095.1 NP_001372024.1 brain-enriched guanylate kinase-associated protein isoform 12
NM_001385096.1 NP_001372025.1 brain-enriched guanylate kinase-associated protein isoform 13
NM_001385097.1 NP_001372026.1 brain-enriched guanylate kinase-associated protein isoform 13
NM_001385098.1 NP_001372027.1 brain-enriched guanylate kinase-associated protein isoform 13
NM_001385099.1 NP_001372028.1 brain-enriched guanylate kinase-associated protein isoform 13
NM_001385100.1 NP_001372029.1 brain-enriched guanylate kinase-associated protein isoform 13
NM_001385101.1 NP_001372030.1 brain-enriched guanylate kinase-associated protein isoform 14
NM_001385102.1 NP_001372031.1 brain-enriched guanylate kinase-associated protein isoform 14
NM_001385103.1 NP_001372032.1 brain-enriched guanylate kinase-associated protein isoform 14
NM_001385104.1 NP_001372033.1 brain-enriched guanylate kinase-associated protein isoform 14
NM_020836.4 NP_065887.1 brain-enriched guanylate kinase-associated protein isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

brain-enriched guanylate kinase-associated protein

  • brain-enriched guanylate kinase-associated homolog

BEGAIN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BEGAIN Q9BUH8 ZNF774 Homo sapiens Q6NX45
Validated Y2H
25416956
Intra
BEGAIN Q9BUH8 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
25416956
Intra
BEGAIN Q9BUH8 ZNF319 Homo sapiens Q9P2F9
Validated Y2H
32296183
Intra
BEGAIN Q9BUH8 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
BEGAIN Q9BUH8 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
BEGAIN Q9BUH8 CDC23 Homo sapiens Q9UJX2
Validated Y2H
32296183
Intra
BEGAIN Q9BUH8 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra
BEGAIN Q9BUH8 ZNF417 Homo sapiens Q8TAU3
Y2H Pooling
16189514
Intra
BEGAIN Q9BUH8 ENKD1 Homo sapiens Q9H0I2
Y2H Pooling
16189514
Intra
BEGAIN Q9BUH8 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
BEGAIN Q9BUH8 RBL1 Homo sapiens P28749
Pull Down
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

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Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01467 BEGAIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BEGAIN RGD RGD:708347
Canis familiaris BEGAIN VGNC VGNC:38429
Felis catus BEGAIN VGNC VGNC:60100
Bos taurus BEGAIN VGNC VGNC:26465
Mus musculus BEGAIN MGD MGI:3044626
Macaca mulatta BEGAIN VGNC VGNC:70124
Others BEGAIN NCBI