ε-Poly-L-lysine hydrochloride (MV 2000-5000)
ε-Poly-L-lysine (Epsilon-polylysine; ε-Polylysine) hydrochloride (MV 2000-5000) is a polycationic antibacterial agent with broad-spectrum activity against Gram-positive bacteria, Gram-negative bacteria, fungi, yeasts and specific bacteriophages. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exerts bactericidal effects through mechanisms such as disrupting microbial membranes, inducing ROS production, inhibiting metabolism and spore germination. ε-Poly-L-lysine hydrochloride (MV 2000-5000) also regulates the expression of multiple key genes including sodA, oxyR and recA. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exhibits properties such as low eukaryotic cytotoxicity, thermal stability and pH stability, and supports tissue regeneration and anti-tumor applications. ε-Poly-L-lysine hydrochloride (MV 2000-5000) can be applied in research fields including bacterial and fungal infections, diabetic ulcers, and methicillin-resistant Staphylococcus aureus infections.
For research use only. We do not sell to patients.
- Purity: 99%
- Formula: (C6H12N2O.ClH)n
- Molecular Weight:2000-5000
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
ε-Poly-L-lysine hydrochloride (MV 2000-5000) (2.5-12.5 μg/mL) inhibits spore germination of Geobacillus stearothermophilus at 2.5 μg/mL, and Bacillus coagulans and B. subtilis at 12.5 μg/mL[1].
ε-Poly-L-lysine hydrochloride (MV 2000-5000) (500 μg/mL) significantly inactivates long-tailed, non-contractile double-stranded DNA bacteriophages, resulting in 0-27% survival rates[1].
ε-Poly-L-lysine hydrochloride (MV 2000-5000) (25-200 μg/mL) inhibits Escherichia coli growth with an MIC of 25-50 μg/mL at pH 5.0-7.0, but its antimicrobial activity is significantly reduced at pH 8.0 (MIC >200 μg/mL)[1].
ε-Poly-L-lysine hydrochloride (MV 2000-5000) exhibits a synergistic preservative effect when combined with 2 mg/mL glycine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Appearance Solid
-
Molecular Weight 2000-5000
-
Formula (C6H12N2O.ClH)n
-
Color White to off-white
-
SMILES
CNC([C@H](CCCCC)N)=O.[n].Cl
-
Synonyms
Epsilon-polylysine hydrochloride (MV 2000-5000); ε-Polylysine hydrochloride (MV 2000-5000); ε-PL hydrochloride (MV 2000-5000)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (Need ultrasonic)
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ε-Poly-L-lysine hydrochloride (MV 2000-5000) Related Classifications
Cat. No.: HY-W250308A
Powered by Bioz
- ε-Poly-L-lysine hydrochloride (MV 2000-5000)
- Epsilon-polylysine hydrochloride (MV 2000-5000)
- ε-Polylysine hydrochloride (MV 2000-5000)
- ε-PL hydrochloride (MV 2000-5000)
- Bacterial
- Fungal
- Reactive Oxygen Species (ROS)
- Gram-positive bacteria
- Gram-negative bacteria
- Geobacillus stearothermophilus
- Escherichia coli O157:H7
- yeasts
- fungi
- Bacillus coagulans
- methicillin-resistant Staphylococcus aureus
- Escherichia coli K-12
- bacteriophages
- Inhibitor
- inhibitor
- inhibit