13-Hydroxyisobakuchiol
13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) that can be isolated from Psoralea corylifolia (L.), is a potent selective monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50 = 0.58 μM) and norepinephrine transporter (NET) (IC50 = 0.69 μM) than for the serotonin transporter (SERT) (IC50 = 312.02 μM). 13-Hydroxyisobakuchiol increases the activity of intact mice and improves the decreased activity of reserpinized mice in vivo. 13-Hydroxyisobakuchiol can be used for the research of disorders such as Parkinson's disease and depression.
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- CAS No.: 178765-49-6
- Formule: C18H24O2
- Masse moléculaire:272.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 0.58 μM (dopamine transporter)
IC50: 0.69 μM (norepinephrine transporter)[1]
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Cell Line
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Type | Value | Description | References |
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| A549 | IC50 |
>10 μM
Compound: 19
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
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[PMID: 25710081] |
| K562 | IC50 |
>10 μM
Compound: 19
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Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
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[PMID: 25710081] |
13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol) (10 μM, 20 min) inhibits dopamine (DA), norepinephrine (NE) and 5-HT uptake by respective Tr-CHO cells (D8, N1, or S6)[1].
13-Hydroxyisobakuchiol (0.03-10 μM, 20 min) inhibits DA and NE uptake by human neuroblastoma cell line SK-N-SH cells[1].
13-Hydroxyisobakuchiol (0.03-333 μM, 15 min) inhibits DA and NE uptake by synaptosomes from rat striatum or hippocampus[1].
13-Hydroxyisobakuchiol (1-500 μM, 4 h) dose-dependently prevents MPP+-induced cell toxicity in D8 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:D8 cells
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Concentration:1, 10, 100, 500 μM
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Incubation Time:4 h
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Result:Dose-dependently prevented MPP+-induced cell toxicity.
Exhibited pEC50 and Emax values for protection against D8 lesion of -0.34 and 82.31%, respectively.
13-Hydroxyisobakuchiol (5, 20, and 100 mg/kg, i.p. once) improves the decreased activity of Reserpinized mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice (2 months old, 18-22g)[1]
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Dosage:4, 20, and 100 mg/kg
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Administration:i.p., once
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Result:Induced a dose-dependent increase in locomotor activity.
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Animal Model:Male C57BL/6 mice (2 months old, 18-22g) subcutaneously injected with 10 mg/kg Reserpine (HY-N0480)[1]
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Dosage:5, 20, and 100 mg/kg
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Administration:i.p., once
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Result:Markedly and dose-dependently increased horizontal movement in in Reserpine-pretreated mice.
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Animal Model:Male C57BL/6 mice (2 months old, 18-22g)[1]
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Dosage:10 and 100 mg/kg
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Administration:i.p., once
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Result:Showed no significant place preference response in the reward system.
Chemical Information
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CAS No. 178765-49-6
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Masse moléculaire 272.38
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Formule C18H24O2
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SMILES
OC1=CC=C(/C=C/[C@](C)(C=C)C/C=C/C(C)(O)C)C=C1
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Synonyms
Delta3,2-Hydroxylbakuchiol
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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