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Cat. No.: HY-116031

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ATC0175 free base

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ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC₅₀ value of 3.4 nM, as well as good selectivity over the Y5 and the α_2A receptors. ATC0175 (free base) is promising for research of obesity.

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CAS No.: 509118-03-0
Formule: C₂₃H₂₅F₂N₅O
Masse moléculaire:425.47

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Please store the product under the recommended conditions in the Certificate of Analysis.

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ATC0175 free base Chemical Structure

CAS No.: 509118-03-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- Cellular Effect
Chemical Information
Publications (1)
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	8.28 nM Compound: ATC-0175	Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay	[PMID: 31678007]
COS-1	IC₅₀	260 nM Compound: 28 (ATC-O175)	Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells	[PMID: 16002290]
COS-1	IC₅₀	2700 nM Compound: 28 (ATC-O175)	Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cells Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cells	[PMID: 16002290]
HEK293	IC₅₀	3.4 nM Compound: 28 (ATC-O175)	Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HEK293 cells Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HEK293 cells	[PMID: 16002290]
HEK293	IC₅₀	7.2 nM Compound: ATC-0175	Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay	[PMID: 19773162]

Chemical Information

CAS No. 509118-03-0
Masse moléculaire 425.47
Formule C₂₃H₂₅F₂N₅O
SMILES

CN(C1=NC(N[C@H]2CC[C@H](CC2)NC(C3=CC(F)=C(C=C3)F)=O)=NC4=C1C=CC=C4)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Eur Arch Psychiatry Clin Neurosci

Genetic factors and symptom dimensions associated with antidepressant treatment outcomes: clues for new potential therapeutic targets?. [Abstract]

2024 Aug 27. PMID: 39191930

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kanuma K, et al. Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3853-6. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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ATC0175 free base

1 Cited Publications

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ATC0175 free base

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ATC0175 free base Related Classifications

HY-116031 Related Classifications