Biotin-epoxomicin
Based on 1 Customer Validation
Biotin-epoxomicin is a Proteasome subunit binder. Biotin-epoxomicin serves as an affinity reagent for identifying proteasomal catalytic subunits, and facilitates affinity purification of active proteasomal subunits for LC-MS identification. Biotin-epoxomicin can be used to study solid tumors derived from B16 melanoma.
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- Pureté: 95.30%
- CAS No.: 1334608-28-4
- Formule: C35H60N6O8S
- Masse moléculaire:724.95
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Ubiquitination Compound Library
HY-L050
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Peptide Library
HY-L105
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Peptide Compound Library
HY-L105S
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Activité biologique
Biotin-epoxomicin (10 μM; 1 hr) covalently binds to the catalytically active β5t subunit in young and adult murine thymus homogenates, enabling affinity purification and definitive LC-MS3 identification of the β5t active-site peptide[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Biotin-IIT-{Leu((2R)-2-methyloxiranyl)}
Biotin-Ile-Ile-Thr-{Leu((2R)-2-methyloxiranyl)}
Chemical Information
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CAS No. 1334608-28-4
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Appearance Solid
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Masse moléculaire 724.95
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Formule C35H60N6O8S
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Color White to off-white
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Sin N, et al. Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorg Med Chem Lett. 1999;9(15):2283-2288. [Content Brief]
[2]. Florea BI, et al. Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Chem Biol. 2010;17(8):795-801. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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