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SOCS4 - suppressor of cytokine signaling 4 Gene

Also Known as SOCS7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 122809

About SOCS4

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:55,027,236-55,049,489 (from NCBI)

This gene has 4 transcripts (splice variants), 263 orthologues and 7 paralogues. Ubiquitous expression in appendix (RPKM 5.4), lymph node (RPKM 5.2) and 25 other tissues.

Summary

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT Inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SOCS4 Products (2)

mRNA	Protein	Name
NM_080867.3	NP_543143.1	suppressor of cytokine signaling 4
NM_199421.2	NP_955453.1	suppressor of cytokine signaling 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25814554	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of epidermal growth factor-activated receptor activity	IDA IDA: Inferred from direct assay	15590694	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
suppressor of cytokine signaling 4	SH2 domain containing SOCS box protein

SOCS4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SOCS4	Q8WXH5	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	SOCS4	Q8WXH5	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	SOCS4	Q8WXH5	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	SOCS4	Q8WXH5	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	SOCS4	Q8WXH5	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	SOCS4	Q8WXH5	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	SOCS4	Q8WXH5	BSCL2	Homo sapiens	J3KQ12	Y2H Pooling	32814053
Intra	SOCS4	Q8WXH5	BSCL2	Homo sapiens	J3KQ12	Validated Y2H	32814053
Intra	SOCS4	Q8WXH5	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32814053
Intra	SOCS4	Q8WXH5	SPTLC1	Homo sapiens	O15269-2	Validated Y2H	32814053
Intra	SOCS4	Q8WXH5	SPTLC1	Homo sapiens	O15269-2	Y2H Array	32814053
Intra	SOCS4	Q8WXH5	SPTLC1	Homo sapiens	O15269-2	Y2H Pooling	32814053
Intra	SOCS4	Q8WXH5	PANK2	Homo sapiens	Q9BZ23-2	Y2H Array	32814053
Intra	SOCS4	Q8WXH5	PANK2	Homo sapiens	Q9BZ23-2	Y2H Pooling	32814053
Intra	SOCS4	Q8WXH5	PANK2	Homo sapiens	Q9BZ23-2	Validated Y2H	32814053
Intra	SOCS4	Q8WXH5	PINK1	Homo sapiens	Q9BXM7	Lumier	25814554
Intra	SOCS4	Q8WXH5	PINK1	Homo sapiens	Q9BXM7	Validated Y2H	25814554
Intra	SOCS4	Q8WXH5	RBP7	Homo sapiens	Q96R05	Y2H Array	25814554
Intra	SOCS4	Q8WXH5	RBP7	Homo sapiens	Q96R05	Lumier	25814554
Intra	SOCS4	Q8WXH5	GRB2	Homo sapiens	P62993	Validated Y2H	25814554
Intra	SOCS4	Q8WXH5	GRB2	Homo sapiens	P62993	Lumier	25814554
Intra	SOCS4	Q8WXH5	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	SOCS4	Q8WXH5	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	SOCS4	Q8WXH5	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	SOCS4	Q8WXH5	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	SOCS4	Q8WXH5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	SOCS4	Q8WXH5	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	SOCS4	Q8WXH5	GARS1	Homo sapiens	P41250	Y2H Array	32814053
Intra	SOCS4	Q8WXH5	GARS1	Homo sapiens	P41250	Y2H Pooling	32814053
Intra	SOCS4	Q8WXH5	GARS1	Homo sapiens	P41250	Validated Y2H	32814053
Intra	SOCS4	Q8WXH5	FRS3	Homo sapiens	O43559	Y2H Array	25814554
Intra	SOCS4	Q8WXH5	PIK3R3	Homo sapiens	Q92569	Validated Y2H	25814554
Intra	SOCS4	Q8WXH5	PIK3R3	Homo sapiens	Q92569	Y2H Array	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Borderline Glaucoma	Preglaucoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-156395	MN551	Inducer	98.01%	Unkown
HY-RS13555	SOCS4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13557	SOCS6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SOCS4	RGD	RGD:1306503
Bos taurus	SOCS4	VGNC	VGNC:35122
Macaca mulatta	SOCS4	VGNC	VGNC:77741
Felis catus	SOCS4	VGNC	VGNC:80837
Mus musculus	SOCS4	MGD	MGI:1914546
Canis familiaris	SOCS4	VGNC	VGNC:46651
Others	SOCS4	NCBI