TRIM33 - tripartite motif containing 33 Gene

Also Known as ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51592

About TRIM33

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,392,790-114,511,203 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues, 80 paralogues and is associated with 80 phenotypes. Ubiquitous expression in testis (RPKM 10.8), endometrium (RPKM 8.6) and 25 other tissues.

Summary

The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

TRIM33 Products (2)

mRNA	Protein	Name
NM_015906.4	NP_056990.3	E3 ubiquitin-protein ligase TRIM33 isoform alpha
NM_033020.3	NP_148980.2	E3 ubiquitin-protein ligase TRIM33 isoform beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables R-SMAD binding	IPI IPI: Inferred from physical interaction	19135894	GOA
enables co-SMAD binding	IPI IPI: Inferred from physical interaction	19135894	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19135894	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	19135894	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	19135894	GOA
involved in regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	19135894	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in nucleus	IDA IDA: Inferred from direct assay	19135894	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM33 Protein Structure

zf-RING_2

zf-B_box

PHD

Bromodomain

0
200
400
600
800
1000
1127 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIM33	RET-fused gene 7 protein

TRIM33 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	TRIM33	Q9UPN9	SMAD2	Homo sapiens	Q15796	Anti Tag CoIP	20603019
Intra	TRIM33	Q9UPN9	SMAD2	Homo sapiens	Q15796	Anti Bait CoIP	19135894
Intra	TRIM33	Q9UPN9	SMAD2	Homo sapiens	Q15796	Anti Tag CoIP	19135894
Intra	TRIM33	Q9UPN9	TRIM24	Homo sapiens	O15164	Anti Tag CoIP	26496610
Intra	TRIM33	Q9UPN9	TRIM24	Homo sapiens	O15164	Anti Bait CoIP	21531907
Intra	TRIM33	Q9UPN9	TRIM24	Homo sapiens	O15164	Anti Tag CoIP	35271311
Intra	TRIM33	Q9UPN9	SMAD4	Homo sapiens	Q13485	Anti Tag CoIP	20603019
Intra	TRIM33	Q9UPN9	SMAD4	Homo sapiens	Q13485	Anti Bait CoIP	21597466
Intra	TRIM33	Q9UPN9	SMAD4	Homo sapiens	Q13485	Anti Bait CoIP	19135894
Intra	TRIM33	Q9UPN9	SMAD4	Homo sapiens	Q13485	Anti Tag CoIP	19135894

Cross: Cross-species interaction Intra: Intraspecies interaction

TRIM33 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81321	TRIM33 Antibody (YA1066)	WB	Human
HY-P81321A	TRIM33 Antibody (YA1066)(PBS only)	WB	Human
HY-P85477	TRIM33 Antibody (YA5169)	WB, IHC-P, ICC/IF, IP, ELISA, IF-Tissue	Human, Mouse, Rat, Bovine, Dog, Pig
HY-P85509	TRIM33 Antibody (YA5201)	WB	Human

Related Diseases

Diseases	Alias
Differentiated Thyroid Carcinoma	Papillary Or Follicular Thyroid Carcinoma Well-Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma
Adult Dermatomyositis	Adult Onset Dermatomyositis Adult Type Dermatomyositis
Antisynthetase Syndrome	As Syndrome Anti-Jo1 Syndrome
Childhood Type Dermatomyositis	Juvenile Dermatomyositis Juvenile Dm Childhood Dermatomyositis Amyopathic Dermatomyositis Adm Dermatomyositis Sine Myositis Dermatomyositis, Childhood Type
Orbital Plasma Cell Granuloma	Orbital Myositis Orbital Pseudotumor Pseudotumor Of Orbit Plasma Cell Granuloma, Orbital
Renal Pelvis Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Kidney Pelvis Squamous Cell Carcinoma Of Renal Pelvis
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Granulomatous Myositis
Chronic Orbital Inflammation	Chronic Inflammation Of Orbit
Muscle Tissue Disease
Laryngeal Small Cell Carcinoma	Small Cell Carcinoma Of Larynx
Exanthem	Exanthema Rash Rashes
Muscular Disease
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15038	TRIM33 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18879	Trim33 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25370	Trim33 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRIM33	VGNC	VGNC:107684
Mus musculus	TRIM33	MGD	MGI:2137357
Macaca mulatta	TRIM33	VGNC	VGNC:79028
Bos taurus	TRIM33	VGNC	VGNC:36329
Rattus norvegicus	TRIM33	RGD	RGD:1307339
Canis familiaris	TRIM33	VGNC	VGNC:47815
Others	TRIM33	NCBI