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PELO - pelota mRNA surveillance and ribosome rescue factor Gene

Also Known as CGI-17; PRO1770

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 53918

About PELO

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:52,787,916-52,804,044 (from NCBI)

This gene has 2 transcripts (splice variants) and 189 orthologues. Ubiquitous expression in adrenal (RPKM 14.2), spleen (RPKM 12.3) and 25 other tissues.

Summary

This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]

PELO Products (1)

mRNA	Protein	Name
NM_015946.5	NP_057030.3	protein pelota homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20406461	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	27543824	GOA
enables stalled ribosome sensor activity	IDA IDA: Inferred from direct assay	27863242	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in nuclear-transcribed mRNA catabolic process, no-go decay	IDA IDA: Inferred from direct assay	23667253	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	21448132	GOA
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	21448132	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of Dom34-Hbs1 complex	IDA IDA: Inferred from direct assay	27863242	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	27863242	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PELO Protein Structure

eRF1_1

eRF1_2

eRF1_3

0
100
200
300
385 a.a.

Protein Preferred Names	Protein Names
protein pelota homolog	pelota homolog

PELO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PELO	Q9BRX2	KRTAP12-2	Homo sapiens	P59991	Y2H Array	32296183
Intra	PELO	Q9BRX2	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	ICAM1	Homo sapiens	P05362	Validated Y2H	32814053
Intra	PELO	Q9BRX2	ICAM1	Homo sapiens	P05362	Y2H Array	32814053
Intra	PELO	Q9BRX2	ICAM1	Homo sapiens	P05362	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	MAT2A	Homo sapiens	P31153	Validated Y2H	32814053
Intra	PELO	Q9BRX2	MAT2A	Homo sapiens	P31153	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	MAT2A	Homo sapiens	P31153	Y2H Array	32814053
Intra	PELO	Q9BRX2	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	PELO	Q9BRX2	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	PELO	Q9BRX2	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	LMO3	Homo sapiens	Q8TAP4-4	Y2H Array	32296183
Intra	PELO	Q9BRX2	LMO3	Homo sapiens	Q8TAP4-4	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	DYNLT1	Homo sapiens	P63172	Y2H Array	32296183
Intra	PELO	Q9BRX2	DYNLT1	Homo sapiens	P63172	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	PELO	Q9BRX2	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	PELO	Q9BRX2	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PELO	Q9BRX2	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	SRPX	Homo sapiens	P78539	BiFC	20406461
Intra	PELO	Q9BRX2	SRPX	Homo sapiens	P78539	Y2H	20406461
Intra	PELO	Q9BRX2	SRPX	Homo sapiens	P78539	Pull Down	20406461
Intra	PELO	Q9BRX2	SRPX	Homo sapiens	P78539	Anti Tag CoIP	20406461
Intra	PELO	Q9BRX2	SRPX	Homo sapiens	P78539	Anti Bait CoIP	20406461
Intra	PELO	Q9BRX2	PPIA	Homo sapiens	P62937-2	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	PPIA	Homo sapiens	P62937-2	Validated Y2H	32814053
Intra	PELO	Q9BRX2	PPIA	Homo sapiens	P62937-2	Y2H Array	32814053
Intra	PELO	Q9BRX2	HBS1L	Homo sapiens	Q9Y450	Y2H Array	32296183
Intra	PELO	Q9BRX2	HBS1L	Homo sapiens	Q9Y450	Y2H Array	31515488
Intra	PELO	Q9BRX2	HBS1L	Homo sapiens	Q9Y450	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	HBS1L	Homo sapiens	Q9Y450	Validated Y2H	32296183
Intra	PELO	Q9BRX2	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	PELO	Q9BRX2	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	PELO	Q9BRX2	HAX1	Homo sapiens	O00165	Anti Tag CoIP	20406461
Intra	PELO	Q9BRX2	HAX1	Homo sapiens	O00165	BiFC	20406461
Intra	PELO	Q9BRX2	HAX1	Homo sapiens	O00165	Pull Down	20406461
Intra	PELO	Q9BRX2	HAX1	Homo sapiens	O00165	Anti Bait CoIP	20406461
Intra	PELO	Q9BRX2	HAX1	Homo sapiens	O00165	Y2H	20406461
Intra	PELO	Q9BRX2	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	PELO	Q9BRX2	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	PELO	Q9BRX2	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	PELO	Q9BRX2	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	PELO	Q9BRX2	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	PELO	Q9BRX2	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	PELO	Q9BRX2	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PELO	Q9BRX2	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PELO	Q9BRX2	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	BAG3	Homo sapiens	O95817	Validated Y2H	32814053
Intra	PELO	Q9BRX2	BAG3	Homo sapiens	O95817	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	BAG3	Homo sapiens	O95817	Y2H Array	32814053
Intra	PELO	Q9BRX2	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	PELO	Q9BRX2	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	PELO	Q9BRX2	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	PELO	Q9BRX2	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	PELO	Q9BRX2	FLNA	Homo sapiens	P21333-2	Y2H Prey Pooling	32296183
Intra	PELO	Q9BRX2	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053
Intra	PELO	Q9BRX2	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	PELO	Q9BRX2	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053
Intra	PELO	Q9BRX2	FLNA	Homo sapiens	P21333-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Progressive Myoclonus Epilepsy 10	Early-Onset Lafora Body Disease Epm10
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-183115	TNG961		/	Unkown
HY-183115A	(Rac)-TNG961		/	Unkown
HY-RS10323	PELO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PELO	MGD	MGI:2145154
Rattus norvegicus	PELO	RGD	RGD:1359591
Bos taurus	PELO	VGNC	VGNC:32743
Felis catus	PELO	VGNC	VGNC:102287
Macaca mulatta	PELO	VGNC	VGNC:84478
Others	PELO	NCBI