PTPN5 - protein tyrosine phosphatase non-receptor type 5 Gene

Also Known as STEP; STEP61; PTPSTEP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84867

About PTPN5

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,727,928-18,792,721 (from NCBI)

This gene has 6 transcripts (splice variants), 202 orthologues and 35 paralogues. Biased expression in brain (RPKM 11.0), testis (RPKM 0.9) and 1 other tissue.

Summary

Enables phosphotyrosine residue binding activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be integral component of membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

PTPN5 Products (6)

mRNA	Protein	Name
NM_001039970.2	NP_001035059.1	tyrosine-protein phosphatase non-receptor type 5 isoform b
NM_001278236.1	NP_001265165.1	tyrosine-protein phosphatase non-receptor type 5 isoform b
NM_001278238.2	NP_001265167.1	tyrosine-protein phosphatase non-receptor type 5 isoform c
NM_001278239.2	NP_001265168.1	tyrosine-protein phosphatase non-receptor type 5 isoform d
NM_006906.2	NP_008837.1	tyrosine-protein phosphatase non-receptor type 5 isoform a
NM_032781.4	NP_116170.3	tyrosine-protein phosphatase non-receptor type 5 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables phosphotyrosine residue binding	IDA IDA: Inferred from direct assay	16441242	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN5 Protein Structure

Y_phosphatase

0
100
200
300
400
500
565 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 5	neural-specific protein-tyrosine phosphatase

PTPN5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PTPN5	P54829	TMEM201	Homo sapiens	Q5SNT2-2	Validated Y2H	32296183
Intra	PTPN5	P54829	SLC35B1	Homo sapiens	P78383	Validated Y2H	32296183
Intra	PTPN5	P54829	CLEC4G	Homo sapiens	Q6UXB4	Validated Y2H	32296183
Intra	PTPN5	P54829	MARCHF5	Homo sapiens	Q9NX47	Validated Y2H	32296183
Intra	PTPN5	P54829	CXCL9	Homo sapiens	Q07325	Y2H Prey Pooling	25416956
Intra	PTPN5	P54829	CXCL9	Homo sapiens	Q07325	Validated Y2H	25416956
Intra	PTPN5	P54829	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	PTPN5	P54829	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	PTPN5	P54829	VTI1B	Homo sapiens	Q9UEU0	Y2H Array	31515488
Intra	PTPN5	P54829	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	25416956
Intra	PTPN5	P54829	TMEM51	Homo sapiens	Q9NW97	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Viral Gastritis
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Phencyclidine Abuse	Pcp Abuse
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-141800	MurA-IN-1	Inhibitor	99.32%	Unkown
HY-155847	LYP-IN-3		99.80%	Unkown
HY-RS11428	PTPN5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20091	Ptpn5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26594	Ptpn5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PTPN5	RGD	RGD:3448
Macaca mulatta	PTPN5	VGNC	VGNC:76606
Canis familiaris	PTPN5	VGNC	VGNC:45178
Felis catus	PTPN5	VGNC	VGNC:69165
Mus musculus	PTPN5	MGD	MGI:97807
Bos taurus	PTPN5	VGNC	VGNC:33540
Others	PTPN5	NCBI