RD-pepcan-11
RD-pepcan-11 is a CB1 receptor agonist. RD-pepcan-11 increases the relative phosphorylation level of ERK1/2. RD-pepcan-11 mediates analgesic effects through interaction with CB1 receptors in a carrageenan-induced mouse inflammatory pain model. RD-pepcan-11 can be used in studies related to inflammatory pain.
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- Formule: C52H86N16O16
- Masse moléculaire:1191.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CB1 |
RD-pepcan-11 (300 μM; 10 min) acts as a CB1 receptor agonist in CB1-overexpressing CHO-K1 cells, with increased agonist activity observed at a concentration of 300 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CB1 receptor-overexpressing CHO-K1 cells
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Concentration:300 μM
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Incubation Time:10 min
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Result:Exhibited higher agonist activity toward the CB1 receptor, as indicated by increased ERK1/2 phosphorylation relative to control conditions.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice (male, 6-8 weeks old, 25 g)[1]
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Dosage:3.25, 7.5, 15, 30 nM/mouse
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Administration:i.t.
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Result:Produced significantly higher AUC values than normal saline control at 7.5, 15, and 30 nM per mouse.
Demonstrated peak antinociceptive effect and AUC value slightly exceeding positive control WIN55212-2 (7.5 nM per mouse) at 30 nM per mouse.
Had antinociceptive effects almost completely blocked by CB1 receptor antagonist AM251 pretreatment.
Showed no significant attenuation of antinociceptive effects by CB2 receptor antagonist AM630 pretreatment.
Chemical Information
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Masse moléculaire 1191.34
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Formule C52H86N16O16
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Sequence
Ser-Ala-Leu-Ser-Asp-Leu-His-Ala-His-Lys-Leu
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Sequence Shortening
SALSDLHAHKL
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RD-pepcan-11 Related Classifications
HY-P11831 Related Classifications
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