Brutieridin
Brutieridin (Compound 1) is a flavanone glycoside that can be isolated from the juice of bergamot (Citrus bergamia). Brutieridin reduces the level of NPC1L1 in intestinal epithelial cells. Brutieridin decreases cholesterol uptake by intestinal epithelial cells. Brutieridin reduces HMGR activity. Brutieridin can be used in the research of hypercholesterolemia.
For research use only. We do not sell to patients.
- CAS No.: 1162664-57-4
- Formula: C34H42O19
- Molecular Weight:754.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Brutieridin (100 μM; 24 h) significantly inhibits cholesterol uptake in Caco-2 cells[2].
Brutieridin (100 μM; 24 h) reduces NPC1L1 protein expression by nearly 50% in Caco-2 cells after 24 h of incubation[2].
Brutieridin (100 μM) reduces HMGR activity by 55%[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco-2 human epithelial colorectal adenocarcinoma cells
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Concentration:100 μM
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Incubation Time:24 h
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Result:Induced a nearly 50% reduction of NPC1L1 protein expression compared to the control group, with a statistically significant difference.
Chemical Information
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CAS No. 1162664-57-4
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Molecular Weight 754.69
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Formula C34H42O19
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SMILES
O=C1C2=C(O)C=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COC(CC(C)(O)CC(O)=O)=O)O)O)O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)C=C2O[C@H](C5=CC(O)=C(C=C5)OC)C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Di Donna L, et al. Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides. J Nat Prod. 2009;72(7):1352-1354. [Content Brief]
[2]. Huang Y, et al. Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells. Nutrients. 2021 Sep 10;13(9):3156. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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