1162664-57-4
Chemical Structure
Brutieridin
- CAS No.: 1162664-57-4
- Formula:C34H42O19
- Molecular Weight:754.69
InChIKey: SHCWOSSXLGIQEQ-CZFUJNBSSA-N
SMILES: O=C1C2=C(O)C=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COC(CC(C)(O)CC(O)=O)=O)O)O)O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)C=C2O[C@H](C5=CC(O)=C(C=C5)OC)C1
Biological Activity: Brutieridin (Compound 1) is a flavanone glycoside that can be isolated from the juice of bergamot (Citrus bergamia). Brutieridin reduces the level of NPC1L1 in intestinal epithelial cells. Brutieridin decreases cholesterol uptake by intestinal epithelial cells. Brutieridin reduces HMGR activity. Brutieridin can be used in the research of hypercholesterolemia[1][2][3].
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Brutieridin | Brutieridin (Compound 1) is a flavanone glycoside that can be isolated from the juice of bergamot (Citrus bergamia). Brutieridin reduces the level of NPC1L1 in intestinal epithelial cells. Brutieridin decreases cholesterol uptake by intestinal epithelial cells. Brutieridin reduces HMGR activity. Brutieridin can be used in the research of hypercholesterolemia. | |||||||||||||||||||||
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- [1]. Di Donna L, et al. Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides. J Nat Prod. 2009;72(7):1352-1354. [Content Brief]
- [2]. Huang Y, et al. Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells. Nutrients. 2021 Sep 10;13(9):3156. [Content Brief]
- [3]. Marco Fiorillo, et al. Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism. Biochimica et Biophysica Acta (BBA)-Bioenergetics
Keywords
