Brutieridin 

Brutieridin (Compound 1) is a flavanone glycoside that can be isolated from the juice of bergamot (Citrus bergamia). Brutieridin reduces the level of NPC1L1 in intestinal epithelial cells. Brutieridin decreases cholesterol uptake by intestinal epithelial cells. Brutieridin can be used in the research of hypercholesterolemia^[1][2].

Brutieridin (100 μM; 24 h) significantly inhibits cholesterol uptake in Caco-2 cells^[2].
Brutieridin (100 μM; 24 h) reduces NPC1L1 protein expression by nearly 50% in Caco-2 cells after 24 h of incubation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

754.69

C₃₄H₄₂O₁₉

1162664-57-4

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Di Donna L, et al. Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides. J Nat Prod. 2009;72(7):1352-1354.  [Content Brief]

  [2]. Huang Y, et al. Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells. Nutrients. 2021 Sep 10;13(9):3156.  [Content Brief]