Stat5b - signal transducer and activator of transcription 5B Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25126

About Stat5b

Primary_assembly 10: 85,705,670-85,775,668 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 286 orthologues, 5 paralogues and is associated with 17 phenotypes. Biased expression in Muscle (RPKM 432.5), Thymus (RPKM 364.1) and 9 other tissues.

Summary

Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; luteinization; and receptor signaling pathway via JAK-STAT. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in growth hormone insensitivity syndrome with immune dysregulation 1 and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022]

Stat5b Products (1)

mRNA Protein Name
NM_022380.2 NP_071775.1 signal transducer and activator of transcription 5B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11562369 RGD
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11064147 RGD
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16527988 RGD
enables chromatin binding IDA
IDA: Inferred from direct assay
20639532 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
11064147 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10720695 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11064147 RGD
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IDA
IDA: Inferred from direct assay
17565389 RGD
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
11064147 RGD
involved in cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
20639532 RGD
involved in liver development IDA
IDA: Inferred from direct assay
17565389 RGD
involved in luteinization IDA
IDA: Inferred from direct assay
10598581 RGD
involved in positive regulation of fibroblast growth factor production IMP
IMP: Inferred from mutant phenotype
16527988 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16527988 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
16527988 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
16527988 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11562369 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
12933671 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16730240 RGD
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
17327369 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
9092792 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
10224108 RGD
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11064147 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Stat5b Protein Structure

STAT_int

STAT_int: pfam02865 (64 - 132)

STAT5_CCD

STAT5_CCD: cd16855 (147 - 338)

STAT5_DBD

STAT5_DBD: cd16849 (340 - 497)

SH2_STAT5b

SH2_STAT5b: cd10420 (581 - 725)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
Protein Preferred Names Protein Names

signal transducer and activator of transcription 5B

  • Signal transducer and activator of transcription 5a

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148813 AK-2292 99.73% Unkown
HY-169182 AK-068 Ligand 99.57% Unkown
HY-136546 Stafia-1 Inhibitor 99.39% Unkown
HY-112647 Stafib-1 Inhibitor 99.25% Unkown
HY-19527 IST5-002 99.83% Unkown
HY-112648 Stafib-2 Inhibitor 99.97% Unkown
HY-112649 Pomstafib-2 99.37% Unkown
HY-RS13893 STAT5B Human Pre-designed siRNA Set A / Unkown
HY-170837 STAT5-IN-3 Inhibitor / Unkown
HY-RS13894 Stat5b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13895 Stat5b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat5b NCBI NCBI:6777