Pomstafib-2

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Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis.

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Pomstafib-2 Chemical Structure

CAS No. : 2332841-83-3

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Description

Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis^[1]^[2].

In Vitro

Pomstafib-2 (compound 8) (0-10 µM; 4 h) decreases the expression of pSTAT5b in a dose-dependent manner in STAT5b-GFP-transfected K562 cells^[1].
Pomstafib-2 (0, 10, 20, 40, 60, 80 µM; 48 h) induces apoptosis in a dose-dependent manner in STAT5-dependent K562 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	K562 leukaemia cells
Concentration:	0, 0.3, 1, 3, 10 µM
Incubation Time:	4 h
Result:	Decreased the expression of pSTAT5b in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:	K562, MDA-MB-231 cells
Concentration:	0, 10, 20, 40, 60, 80 µM
Incubation Time:	48 h
Result:	Induced apoptosis in a dose-dependent manner in K562 cells, does not increased the apoptotic rate of STAT5-independent MDA-MB-231 cells.

Molecular Weight

1101.03

Formula

C₅₂H₆₆N₂O₂₀P₂

CAS No.

2332841-83-3

SMILES

O=C(NCC1=CC=C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)=C1)COC2=CC=C(C(NC3=CC=C(OC4=CC=CC=C4)C=C3)=O)C=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Elumalai N, et al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7(1):819. [Content Brief]

[2]. Gräb J, et al. The STAT5b Linker Domain Mediates the Selectivity of Catechol Bisphosphates for STAT5b over STAT5a. ACS Chem Biol. 2019 Apr 19;14(4):796-805. [Content Brief]

Pomstafib-2 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomstafib-22332841-83-3Pomstafib2Pomstafib 2STATApoptosisK562MDA-MB-231 cellsapoptosispSTAT5bInhibitorinhibitorinhibit

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