1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. Stafib-2

Stafib-2 

Cat. No.: HY-112648 Purity: 95.64%
Handling Instructions

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively. Stafib-2 exhibits poor cell permeability.

For research use only. We do not sell to patients.

Stafib-2 Chemical Structure

Stafib-2 Chemical Structure

CAS No. : 2097938-74-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 709 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3000 Get quote
100 mg USD 4600 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively. Stafib-2 exhibits poor cell permeability[1].

IC50 & Target

IC50: 82 nM (STAT5b)[1]

In Vitro

Stafib-2 has an extremely high affinity for STAT5b (Ki=8.8 nM)[1].
Stafib-2 (3-10 μM; 4-48 h) does not show significant activity in K562 and MDA-MB-231 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

644.46

Formula

C₂₈H₂₆N₂O₁₂P₂

CAS No.
SMILES

O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=C(OCC(NCC4=CC=C(OP(O)(O)=O)C(OP(O)(O)=O)=C4)=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

Stafib-2Stafib2Stafib 2STATtranscriptionfactorSTAT5bSTAT5aInhibitorinhibitorinhibit

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Product Name:
Stafib-2
Cat. No.:
HY-112648
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