Biotin-β-Amyloid (17-40)
Biotin-β-Amyloid (17-40) is a N-terminal-labelled biotinylated amyloid-β(1-40) peptide. β-Amyloid (17-40) is a 24-residue fragment of the Aβ protein via post-translational processing of amyloid precursor protein (APP).
For research use only. We do not sell to patients.
- Formula: C120H192N28O33S2
- Molecular Weight:2619.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
β-Amyloid (17-40) (5-10 μM) increases the rate of Aβ (1-40) aggregation more than addition of equivalent amounts of β-Amyloid (17-28), because it facilitates aggregation of Aβ40 through two different mechanisms, one promoted by residues 17-21 and the second by residues 30-35[1]. Biotin is widely used throughout the biotechnology industry to conjugate proteins for biochemical assays. Biotin can be used for qualitative and quantitative detection, labelling or immobilisation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Biotin-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
Biotin-LVFFAEDVGSNKGAIIGLMVGGVV
Chemical Information
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Molecular Weight 2619.20
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Formula C120H192N28O33S2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ruitian Liu, et al. Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation. J Neurosci Res. 2004 Jan 15;75(2):162-71. [Content Brief]
[2]. J Näslund, et al. The metabolic pathway generating p3, an A beta-peptide fragment, is probably non-amyloidogenic. Biochem Biophys Res Commun. 1994 Oct 28;204(2):780-7 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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