LRRC4 - leucine rich repeat containing 4 Gene

Also Known as NAG14; NGL-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64101

About LRRC4

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,027,071-128,032,128 (from NCBI)

This gene has 4 transcripts (splice variants), 262 orthologues and 22 paralogues. Biased expression in brain (RPKM 14.4), adrenal (RPKM 3.2) and 12 other tissues.

Summary

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008]

LRRC4 Products (1)

mRNA Protein Name
NM_022143.5 NP_071426.1 leucine-rich repeat-containing protein 4 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21946559 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC4 Protein Structure

LRR_5

LRR_5: Leucine rich repeats (6 copies) (89 - 204)

LRR_8

LRR_8: Leucine rich repeat (220 - 278)

I-set

I-set: Immunoglobulin I-set domain (355 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 653 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat-containing protein 4

  • brain tumor associated protein LRRC4

LRRC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRRC4 Q9HBW1 NTNG1 Homo sapiens Q9Y2I2
SPR
21946559
Intra
LRRC4 Q9HBW1 NTNG2 Homo sapiens Q96CW9
Light Scattering
21946559
Intra
LRRC4 Q9HBW1 NTNG2 Homo sapiens Q96CW9
X-Ray Diffraction
21946559
Intra
LRRC4 Q9HBW1 NTNG2 Homo sapiens Q96CW9
SPR
21946559
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRRC4 Proteins

Cat. No. Product Name Accession Purity
HY-P78777 LRRC4 Protein, Human (489a.a, HEK293, His) AAI11562 (A39-K527) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Rela Fusion-Positive Ependymoma

  • Supratentorial C11orf95-Rela Fused Ependymoma

  • C11orf95 Fusion-Positive Supratentorial Ependymoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07818 LRRC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07821 LRRC4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07822 LRRC4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18668 Lrrc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20174 Lrrc4c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25154 Lrrc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26678 Lrrc4c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992426 NS101 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LRRC4 VGNC VGNC:74293
Bos taurus LRRC4 VGNC VGNC:31014
Canis familiaris LRRC4 VGNC VGNC:42797
Rattus norvegicus LRRC4 RGD RGD:1560026
Mus musculus LRRC4 MGD MGI:2182081
Felis catus LRRC4 VGNC VGNC:80614
Others LRRC4 NCBI