H-Pro-Lys-OH
Based on 1 Customer Validation
H-Pro-Lys-OH is a dipeptide containing proline and lysine, which can serve as a substrate for iminodipeptidase (prolinase). H-Pro-Lys-OH can also be used for the synthesis of polypeptides.
For research use only. We do not sell to patients.
- Purity: 99.69%
- CAS No.: 71227-70-8
- Formula: C11H21N3O3
- Molecular Weight:243.30
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | IC50 |
>16 mM
Compound: 62
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Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
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[PMID: 16759105] |
Pro-Lys
PK
Chemical Information
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CAS No. 71227-70-8
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Appearance Solid
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Molecular Weight 243.30
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Formula C11H21N3O3
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 33.33 mg/mL (136.99 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Mayer H, et al. The cleavage of prolyl peptides by kidney peptidases. Purification of iminodipeptidase (Prolinase). Hoppe Seylers Z Physiol Chem. 1973 Apr;354(4):371-9. [Content Brief]
[2]. Mentlein R. Proline residues in the maturation and degradation of peptide hormones and neuropeptides. FEBS Lett. 1988 Jul 18;234(2):251-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.1102 mL | 20.5508 mL | 41.1015 mL | 102.7538 mL |
| 5 mM | 0.8220 mL | 4.1102 mL | 8.2203 mL | 20.5508 mL | |
| 10 mM | 0.4110 mL | 2.0551 mL | 4.1102 mL | 10.2754 mL | |
| 15 mM | 0.2740 mL | 1.3701 mL | 2.7401 mL | 6.8503 mL | |
| 20 mM | 0.2055 mL | 1.0275 mL | 2.0551 mL | 5.1377 mL | |
| 25 mM | 0.1644 mL | 0.8220 mL | 1.6441 mL | 4.1102 mL | |
| 30 mM | 0.1370 mL | 0.6850 mL | 1.3701 mL | 3.4251 mL | |
| 40 mM | 0.1028 mL | 0.5138 mL | 1.0275 mL | 2.5688 mL | |
| 50 mM | 0.0822 mL | 0.4110 mL | 0.8220 mL | 2.0551 mL | |
| 60 mM | 0.0685 mL | 0.3425 mL | 0.6850 mL | 1.7126 mL | |
| 80 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2844 mL | |
| 100 mM | 0.0411 mL | 0.2055 mL | 0.4110 mL | 1.0275 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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