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Scn5a - sodium voltage-gated channel alpha subunit 5 Gene

Also Known as SCAL; Nav1.5

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25665

About Scn5a

Primary_assembly 8: 119,220,905-119,318,769 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 94 orthologues, 26 paralogues and is associated with 58 phenotypes. Restricted expression toward (RPKM 231.9).

Summary

Enables ankyrin binding activity; Fibroblast Growth Factor binding activity; and voltage-gated Sodium Channel activity involved in cardiac muscle cell action potential. Involved in several processes, including animal organ development; response to denervation involved in regulation of muscle adaptation; and sodium ion import across plasma membrane. Located in T-tubule and intercalated disc. Biomarker of brain ischemia and congestive heart failure. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); intrinsic cardiomyopathy (multiple); and sudden infant death syndrome. Orthologous to human SCN5A (sodium voltage-gated channel alpha subunit 5). [provided by Alliance of Genome Resources, Apr 2022]

Scn5a Products (2)

mRNA	Protein	Name
NM_001160162.2	NP_001153634.2	sodium channel protein type 5 subunit alpha isoform 2
NM_013125.3	NP_037257.2	sodium channel protein type 5 subunit alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ankyrin binding	IDA IDA: Inferred from direct assay	15579534	RGD
enables ankyrin binding	IPI IPI: Inferred from physical interaction	15579534	RGD
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	12401812	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11238277	RGD
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	29457789	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in brainstem development	IEP IEP: Inferred from expression pattern	22331407	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	22331407	RGD
involved in membrane depolarization during cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	29457789	RGD
involved in odontogenesis of dentin-containing tooth	IEP IEP: Inferred from expression pattern	21640979	RGD
involved in positive regulation of action potential	IMP IMP: Inferred from mutant phenotype	22336133	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16331678	RGD
involved in positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	17259145	RGD
involved in response to denervation involved in regulation of muscle adaptation	IMP IMP: Inferred from mutant phenotype	22336133	RGD
involved in sodium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	29457789	RGD
involved in sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	12562928	RGD
involved in telencephalon development	IEP IEP: Inferred from expression pattern	22331407	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in T-tubule	IDA IDA: Inferred from direct assay	15579534	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	15579534	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	21617128	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn5a Protein Structure

Ion_trans

Na_trans_cytopl

Ion_trans

Na_trans_assoc

Ion_trans

Na_channel_gate

Ion_trans

0
400
800
1200
1600
2020 a.a.

Protein Preferred Names	Protein Names
sodium channel protein type 5 subunit alpha	sodium channel protein cardiac muscle subunit alpha sodium channel protein type V subunit alpha sodium channel, voltage-gated, type 5, alpha subunit sodium channel, voltage-gated, type V, alpha polypeptide sodium channel, voltage-gated, type V, alpha subunit voltage-gated sodium channel Nav1.5c voltage-gated sodium channel subunit alpha Nav1.5

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0405	Bupivacaine	Inhibitor	99.95%	Yes
HY-B0405A	Bupivacaine hydrochloride	Inhibitor	99.85%	Yes
HY-B0405AR	Bupivacaine hydrochloride (Standard)	Inhibitor	99.99%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W415121	Bupivacaine hydrochloride monohydrate	Inhibitor	/	Phase 4

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0405S	Bupivacaine-d9		99.04%	Unkown
HY-RS12541	SCN5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W045132	N-Desbutyl Bupivacaine		/	Unkown
HY-RS12542	Scn5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12543	Scn5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W045132S	N-Desbutyl bupivacaine-d6		/	Unkown
HY-W702016	Bupivacaine-d9 hydrochloride		/	Unkown
HY-W585873	Bupivacaine N-oxide hydrochloride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scn5a	NCBI	NCBI:6331