Bupivacaine-d9
Based on 1 Customer Validation
Bupivacaine-d99 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
For research use only. We do not sell to patients.
- Purity: 99.04%
- CAS No.: 474668-57-0
- Formula: C18H19D9N2O
- Molecular Weight:297.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NMDA Receptor |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 474668-57-0
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Unlabeled Cas 38396-39-3
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Appearance Solid
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Molecular Weight 297.48
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Formula C18H19D9N2O
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Color White to off-white
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SMILES
CC1=CC=CC(C)=C1NC(C2N(CCCC2)C([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (336.16 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Stoetzer C, et al. Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med. 2017;42(4):462-468. [Content Brief]
[2]. Schwoerer AP, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015;120(6):1226-1234. [Content Brief]
[3]. Paganelli MA, et al. Actions of bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015;35(2):831-842. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.3616 mL | 16.8079 mL | 33.6157 mL | 84.0393 mL |
| 5 mM | 0.6723 mL | 3.3616 mL | 6.7231 mL | 16.8079 mL | |
| 10 mM | 0.3362 mL | 1.6808 mL | 3.3616 mL | 8.4039 mL | |
| 15 mM | 0.2241 mL | 1.1205 mL | 2.2410 mL | 5.6026 mL | |
| 20 mM | 0.1681 mL | 0.8404 mL | 1.6808 mL | 4.2020 mL | |
| 25 mM | 0.1345 mL | 0.6723 mL | 1.3446 mL | 3.3616 mL | |
| 30 mM | 0.1121 mL | 0.5603 mL | 1.1205 mL | 2.8013 mL | |
| 40 mM | 0.0840 mL | 0.4202 mL | 0.8404 mL | 2.1010 mL | |
| 50 mM | 0.0672 mL | 0.3362 mL | 0.6723 mL | 1.6808 mL | |
| 60 mM | 0.0560 mL | 0.2801 mL | 0.5603 mL | 1.4007 mL | |
| 80 mM | 0.0420 mL | 0.2101 mL | 0.4202 mL | 1.0505 mL | |
| 100 mM | 0.0336 mL | 0.1681 mL | 0.3362 mL | 0.8404 mL |
Bupivacaine-d9 Related Classifications
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