ALK inhibitor 1
Based on 1 publication(s) in Google Scholar
ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM).
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- Pureza: 99.16%
- No. CAS: 761436-81-1
- Fòrmula: C23H28BrN7O3S
- Peso molecular:562.48
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) ALK inhibitor 1
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Actividad biológica
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TSSK2 31 nM (IC50) |
Chemical Information
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No. CAS 761436-81-1
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Appearance Solid
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Peso molecular 562.48
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Fòrmula C23H28BrN7O3S
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Color White to off-white
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SMILES
O=S(C1=C(NC2=C(Br)C=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=N2)C=CC=C1)(NC)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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ChemMedChem
Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2). [Abstract]2017 Nov 22;12(22):1857-1865. PMID: 28952188
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (177.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
1M HCl : 100 mg/mL (177.78 mM; ultrasonic and adjust pH to 1 with HCl)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 1M HCl | 1 mM | 1.7778 mL | 8.8892 mL | 17.7784 mL | 44.4460 mL |
| 5 mM | 0.3556 mL | 1.7778 mL | 3.5557 mL | 8.8892 mL | |
| 10 mM | 0.1778 mL | 0.8889 mL | 1.7778 mL | 4.4446 mL | |
| 15 mM | 0.1185 mL | 0.5926 mL | 1.1852 mL | 2.9631 mL | |
| 20 mM | 0.0889 mL | 0.4445 mL | 0.8889 mL | 2.2223 mL | |
| 25 mM | 0.0711 mL | 0.3556 mL | 0.7111 mL | 1.7778 mL | |
| 30 mM | 0.0593 mL | 0.2963 mL | 0.5926 mL | 1.4815 mL | |
| 40 mM | 0.0444 mL | 0.2222 mL | 0.4445 mL | 1.1112 mL | |
| 50 mM | 0.0356 mL | 0.1778 mL | 0.3556 mL | 0.8889 mL | |
| 60 mM | 0.0296 mL | 0.1482 mL | 0.2963 mL | 0.7408 mL | |
| 80 mM | 0.0222 mL | 0.1111 mL | 0.2222 mL | 0.5556 mL | |
| 100 mM | 0.0178 mL | 0.0889 mL | 0.1778 mL | 0.4445 mL |
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