Biotin-epoxomicin
Based on 1 Customer Validation
Biotin-epoxomicin is a Proteasome subunit binder. Biotin-epoxomicin serves as an affinity reagent for identifying proteasomal catalytic subunits, and facilitates affinity purification of active proteasomal subunits for LC-MS identification. Biotin-epoxomicin can be used to study solid tumors derived from B16 melanoma.
For research use only. We do not sell to patients.
- Purity: 95.30%
- CAS No.: 1334608-28-4
- Formula: C35H60N6O8S
- Molecular Weight:724.95
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
Metabolism/Protease Compound Library
HY-L012
-
Anti-Cancer Compound Library
HY-L025
-
Ubiquitination Compound Library
HY-L050
-
Peptide Library
HY-L105
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Peptide Compound Library
HY-L105S
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Biotin-epoxomicin (10 μM; 1 hr) covalently binds to the catalytically active β5t subunit in young and adult murine thymus homogenates, enabling affinity purification and definitive LC-MS3 identification of the β5t active-site peptide[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Biotin-IIT-{Leu((2R)-2-methyloxiranyl)}
Biotin-Ile-Ile-Thr-{Leu((2R)-2-methyloxiranyl)}
Chemical Information
-
CAS No. 1334608-28-4
-
Appearance Solid
-
Molecular Weight 724.95
-
Formula C35H60N6O8S
-
Color White to off-white
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
-
Data Sheet (268 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
-
Handling Instructions (2659 KB)
References
[1]. Sin N, et al. Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorg Med Chem Lett. 1999;9(15):2283-2288. [Content Brief]
[2]. Florea BI, et al. Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Chem Biol. 2010;17(8):795-801. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz