KRT17 - keratin 17 Gene

Also Known as PC; K17; PC2; 39.1; CK-17; PCHC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3872

About KRT17

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,619,442-41,624,575 (from NCBI)

This gene has 8 transcripts (splice variants), 80 orthologues, 68 paralogues and is associated with 6 phenotypes. Biased expression in urinary bladder (RPKM 147.9), skin (RPKM 53.6) and 3 other tissues.

Summary

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and Other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

KRT17 Products (1)

mRNA Protein Name
NM_000422.3 NP_000413.1 keratin, type I cytoskeletal 17

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT17 Protein Structure

Filament

Filament: Intermediate filament protein (84 - 393)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
Protein Preferred Names Protein Names

keratin, type I cytoskeletal 17

  • cytokeratin-17

KRT17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KRT17 Q04695 EEF1G Homo sapiens P26641
Anti Bait CoIP
17906640
Intra
KRT17 Q04695 CCDC85B Homo sapiens Q15834
Y2H Pooling
16189514
Intra
KRT17 Q04695 CCDC85B Homo sapiens Q15834
Pull Down
16189514
Intra
KRT17 Q04695 TRIM69 Homo sapiens Q86WT6
Y2H Array
25416956
Intra
KRT17 Q04695 TRIM69 Homo sapiens Q86WT6
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

KRT17 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82789 Cytokeratin 17 Antibody (YA2534) WB, IHC-P, IP Human
HY-P82789A Cytokeratin 17 Antibody (YA2534)(PBS only) WB, IHC-P, IP Human
HY-P83702 Cytokeratin 17 Antibody (YA3438) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P85903 Cytokeratin 17 Antibody (YA5595) IHC-P, WB, ICC/IF, ELISA Human, Mouse, Rat
HY-P85989 Cytokeratin 17 Antibody (YA5681) IHC-P, ELISA Human, Mouse, Rat
HY-P86722 Cytokeratin 17 Antibody (YA6414) WB, IHC-P, IHC-F, IF-Tissue Human
HY-P86722A Cytokeratin 17 Antibody (YA6414)(PBS only) WB, IHC-P, IHC-F, IF-Tissue Human

Related Diseases

Diseases Alias
Steatocystoma Multiplex

  • Sebocystomatosis

  • Multiple Sebaceous Cysts

  • Multiplex Steatocystoma

  • Sebaceous Cysts, Multiple

  • SM
Pachyonychia Congenita 2

  • Pachyonychia Congenita, Type 2

  • PC2

  • Pachyonychia Congenita, Jackson-Lawler Type, Formerly

  • Pachyonychia Congenita Jackson-Lawler Type
Pachyonychia Congenita 1

  • Pachyonychia Congenita

  • Jadassohn-Lewandowsky Syndrome

  • Pachyonychia Congenita Syndrome

  • PC1

  • Pachyonychia Congenita, Jadassohn-Lewandowsky Type

  • Congenital Pachyonychia

  • Pachyonychia Congenita, Type 1

  • Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

  • Jadassohn-Lewandowsky Syndrome, Formerly

  • Jackson-Lawler Type Pachyonychia Congenita

  • Pachyonychia Congenita Type 1

  • Jackson-Lawler Syndrome

  • Jadassohn-Lewandowski Syndrome

  • Pc

  • Pachyonychia Congenita Jackson-Lawler Type

  • Pachyonychia Congenita Jadassohn-Lewandowsky Type

  • Pachyonychia Congenita Jackson Lawler Type

  • Pc-1

  • Pachyonychia Congenita, Jadassohn Lewandowsky Type

  • Pachyonychia Congenita, Type 2
Nail Disorder, Nonsyndromic Congenital, 4

  • Anonychia Congenita

  • Anonychia

  • Hyponychia Congenita

  • NDNC4

  • Anonychia/Hyponychia Congenita

  • Nonsyndromic Congenital Nail Disorder 4

  • Isolated Congenital Anonychia

  • Anonychia Congenita Totalis

  • Anonychia Totalis

  • Autosomal Recessive Nonsyndromic Congenital Nail Disorder-4

  • Congenital Anonychia

  • Nonsyndromic Congenital Nail Disorder, 4

  • Absent Nails

  • Aplastic Nails

  • Congenital Absence Of Nails

  • Isolated Anonychia

  • Nail Disorder, Non-Syndromic Congenital, 4

  • Nail Disorder, Nonsyndromic, Congenital, Type 4
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Pili Torti, Early-Onset

  • Pili Torti

  • Twisted Hair

  • Pili Torti, Ronchese Type

  • Coarse, Dry, Lusterless Hair Which Breaks Off Easily
Keratoacanthoma

  • Ka - [Keratoacanthoma]

  • Well-Differentiated Squamous Cell Carcinoma
Epidermolysis Bullosa Simplex

  • Ebs

  • Epidermolysis Bullosa Intraepidermic

  • Epidermolytic Epidermolysis Bullosa
Cervical Intraepithelial Neoplasia

  • CIN
Palmoplantar Keratoderma, Nonepidermolytic

  • Nonepidermolytic Palmoplantar Keratoderma

  • NEPPK

  • Tylosis

  • Unna-Thost Syndrome

  • Keratoderma, Palmoplantar, Diffuse

  • Ppkne

  • Keratoderma, Nonepidermolytic Palmoplantar

  • Diffuse Nonepidermolytic Palmomplantar Keratoderma

  • Thost-Unna Syndrome

  • Non-Epidermolytic Palmoplantar Keratoderma

  • Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type

  • Diffuse Palmoplantar Keratoderma, Bothnian Type

  • Krt1-Related Diffuse Nonepidermolytic Keratoderma

  • Krt1-Related Diffuse Neppk

  • Keratoderma, Palmoplantar, Non-Epidermolytic

  • Nonepidermolytic Unna-Thost Disease

  • Non-Epidermolytic Unna-Thost Disease

  • Keratoderma, Palmoplantar, Nonepidermolytic

  • Hyperkeratosis
Psoriasis
Cervical Adenoid Basal Carcinoma
Clear Cell Basal Cell Carcinoma

  • Skin Clear Cell Basal Cell Carcinoma
Epidermoid Cysts

  • Epidermoid Cyst

  • Sebaceous Cyst

  • Epidermal Inclusion Cyst

  • Epidermal Cyst
Epidermolytic Hyperkeratosis

  • Bullous Congenital Ichthyosiform Erythroderma

  • Bullous Ichthyosiform Erythroderma

  • EHK

  • Bullous Erythroderma Ichthyosiformis Congenita Of Brocq

  • Bcie

  • Bie

  • Epidermolytic Ichthyosis

  • Ichthyosis Bullosa Of Siemens

  • Superficial Epidermolytic Ichthyosis

  • Hyperkeratosis, Epidermolytic

  • Congenital Bullous Ichthyosiform Erythroderma

  • Bullous Type Ichthyosis

  • Epidermolytic Palmoplantar Hyperkeratosis

  • Bullous Ichthyosiform Erythroderma Congenita

  • Bullous Erythroderma Ichthyosiforme

  • Sei

  • Epidermolytic Hyperkeratosis Late-Onset

  • Epidermolytic Hyperkeratosis, Late-Onset
Palmoplantar Keratoderma, Epidermolytic

  • Epidermolytic Palmoplantar Keratoderma

  • EPPK

  • Keratosis Palmaris Et Plantaris Familiaris

  • Tylosis

  • Keratosis Of Greither

  • Diffuse Nonepidermolytic Palmoplantar Keratoderma

  • Keratoderma, Palmoplantar, Epidermolytic

  • Unna-Thost Palmoplantar Keratoderma

  • Epidermolytic Palmoplantar Keratoderma Of Voerner

  • Ppke

  • Keratoderma, Epidermolytic Palmoplantar

  • Palmoplantar Keratoderma, Vorner Type

  • Hyperkeratosis, Localized Epidermolytic

  • Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type

  • Epidermolytic Palmoplantar Keratoderma Of Vörner

  • Hyperkeratosis Palmoplantar Localized Epidermolytic

  • Diffuse Neppk

  • Ppk Diffusa Circumscripta

  • Thost-Unna Disease

  • Thost-Unna Palmoplantar Keratoderma

  • Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type

  • Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type

  • Epidermolytic Palmoplantar Keratoderma Of Vorner

  • Ehppk

  • Epidermolytic Unna-Thost Disease

  • Localized Epidermolytic Hyperkeratosis

  • Palmoplantar Keratoderma Vorner Type

  • Unilateral Palmoplantar Verrucous Nevus

  • UPVN

  • Keratoderma, Palmoplantar, Diffuse

  • Hyperkeratosis

  • Palmoplantar Keratoderma, Nonepidermolytic

  • Epidermolytic Palmoplantar Keratoderma Vorner Type

  • Type B Tylosis

  • Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

  • Type A Tylosis
Ectodermal Dysplasia

  • Congenital Ectodermal Defect

  • Congenital Ectodermal Dysplasia

  • Ectodermal Dysplasia Syndrome

  • Dysplasia, Ectodermal
Basal Cell Carcinoma

  • Basal Cell Cancer

  • Basal Cell Neoplasm

  • Basal Cell Carcinoma Of Skin

  • Malignant Basal Cell Tumor

  • Basal Cell Tumor

  • Epithelioma Basal Cell

  • Malignant Basal Cell Neoplasm

  • Rodent Ulcer

  • Carcinoma Basal Cell

  • Neoplasms, Basal Cell

  • Basal Cell Carcinomas

  • Experimental Organism Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Basalioma

  • Basal Cell Epithelioma Of Skin

  • Bcc - [Basal Cell Carcinoma] Of Skin

  • Rodent Ulcer Of Skin

  • Rodent Ulcer Of Unspecified Site

  • Basal Cell Epithelioma Of Unspecified Site
Monilethrix

  • Beaded Hair

  • MNLIX

  • Nodose Hair

  • Moniliform Hair Syndrome
Acrokeratosis Verruciformis

  • Acrokeratosis Verruciformis Of Hopf

  • Hopf Disease

  • AKV

  • Akv Of Hopf
Inverted Follicular Keratosis

  • Inverted Folicular Keratosis

  • Seborrheic Keratosis
Palmoplantar Keratosis

  • Palmoplantar Keratoderma

  • Keratosis Palmaris Et Plantaris

  • Palmo-Plantar Keratodermas

  • Keratoderma, Palmoplantar

  • Keratoderma Palmoplantar

  • Keratoderma, Palmoplantar, Diffuse

  • Hyperkeratosis Of Palms And Soles

  • Palmoplantar Hyperkeratosis
Follicular Infundibulum Tumor

  • Tumor Of Follicular Infundibulum

  • Follicular Infundibulum Tumour

  • Neoplasm Of The Follicular Infundibulum

  • Tumour Of Follicular Infundibulum
Large Cell Acanthoma
Focal Palmoplantar Keratoderma

  • Focal Ppk

  • Focal Keratosis Palmoplantaris

  • Focal Palmoplantar Hyperkeratosis
Contact Dermatitis

  • Contact Dermatitis/Eczema

  • Contact Eczema

  • Dermatitis Venenata

  • Dermatitis, Venenata

  • Dermatitis Contact

  • Dermatitis, Contact
Epidermolysis Bullosa

  • Acantholysis Bullosa

  • Eb
Eccrine Papillary Adenoma

  • Papillary Eccrine Adenoma

  • Eccrine Papillary Adenoma Of Skin
Intrahepatic Gall Duct Cancer

  • Malignant Neoplasm Of Intrahepatic Bile Ducts

  • Malignant Neoplasm Of Intrahepatic Gall Duct

  • Ca Intrahepatic Bile Ducts

  • Malignant Neoplasm Of Intrahepatic Biliary Passages

  • Intrahepatic Bile Duct Carcinoma
Extrahepatic Bile Duct Adenocarcinoma

  • Adenocarcinoma Of The Extrahepatic Bile Duct

  • Adenocarcinoma Of Extrahepatic Bile Duct
Morpheaform Basal Cell Carcinoma

  • Basal Cell Carcinoma, Morphea

  • Cicatricial Basal-Cell Carcinoma

  • Morphea-Type Basal Cell Carcinoma

  • Morpheic Basal Cell Carcinoma
Keratosis

  • Actinic Keratosis

  • Hyperkeratosis
Ampulla Of Vater Cancer

  • Ampulla Of Vater Carcinoma

  • Ampullary Carcinoma

  • Malignant Tumour Of Ampulla Of Vater

  • Carcinoma Of Ampulla Of Vater

  • Carcinoma Of The Ampulla Of Vater

  • Ampulloma
Glossitis

  • Inflammation Of Tongue

  • Tongue Inflammation

  • Glazed Tongue
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse

  • PPKNEFD

  • Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma

  • Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering

  • Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse

  • Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma

  • Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse
Cervical Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of The Cervix Uteri

  • Squamous Cell Carcinoma Of Cervix
Uterus Carcinoma In Situ
Cervix Uteri Carcinoma In Situ

  • Carcinoma In Situ Of Cervix

  • Carcinoma In Situ Of Uterine Cervix

  • Cervical Intraepithelial Neoplasia

  • Carcinoma Of Cervix Stage 0

  • Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia

  • Cervix Ca In Situ

  • Cin Iii

  • Cin Iii - Carcinoma In Situ Of Cervix

  • Cin Iii - Severe Dyskaryosis

  • Severe Dysplasia Of Cervix

  • Severe Dysplasia Of The Cervix Uteri

  • Squamous Intraepithelial Neoplasia, Grade Iii

  • Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Polycystic Liver Disease 1 With Or Without Kidney Cysts

  • Polycystic Liver Disease 1

  • PCLD1

  • Cyst

  • Liver Disease, Polycystic, Type 1

  • Polycystic Liver Disease
Infiltrative Basal Cell Carcinoma

  • Skin Infiltrating Basal Cell Carcinoma
Basaloid Squamous Cell Carcinoma

  • Basaloid Carcinoma
Malignant Syringoma

  • Microcystic Adnexal Carcinoma

  • Microcystic Adnexal Carcinoma Of Skin

  • Syringomatous Carcinoma

  • Eccrine Epithelioma
Gallbladder Adenocarcinoma

  • Adenocarcinoma Of The Gallbladder

  • Carcinoma Of The Gallbladder
Hair Follicle Neoplasm

  • Hair Matrix Neoplasm

  • Hair Matrix Tumour
Corneal Dystrophy
Cribriform Carcinoma

  • Ductal Carcinoma, Cribriform Type

  • Carcinoma Cribriform

  • Carcinoma, Cribriform
Synchronous Bilateral Breast Carcinoma
Sebaceous Gland Disease

  • Sebaceous Gland Anomaly

  • Sebaceous Gland Diseases
Borst-Jadassohn Intraepidermal Carcinoma

  • Intraepidermal Epithelioma Of Jadassohn

  • Bowen'S Disease, Clonal
Keratosis, Seborrheic

  • Seborrheic Keratosis

  • Keratosis, Seborrheic, Somatic

  • Basal Cell Papilloma

  • Keratosis Seborrheica

  • KERSEB
Pilomatrixoma

  • Pilomatricoma

  • PTR

  • Epithelioma Calcificans Of Malherbe

  • Benign Pilomatricoma

  • Calcifying Epithelioma Of Malherbe

  • Pilomatricoma, Somatic

  • Benign Pilomatrixoma

  • Malherbe Calcifying Epithelioma
Epidermolysis Bullosa Simplex Localized Type

  • Epidermolysis Bullosa Simplex, Weber-Cockayne Type

  • Weber-Cockayne Syndrome

  • Ebs-Loc

  • Epidermolysis Bullosa Simplex Of Palms And Soles

  • Epidermolysis Bullosa Simplex Weber-Cockayne Type

  • Epidermolysis Bullosa Simplex, Localized

  • Epidermolysis Bullosa Of Hands And Feet

  • Weber-Cockayne Type Epidermolysis Bullosa Simplex

  • Localized Epidermolysis Bullosa Simplex

  • Localized Ebs
Pre-Malignant Neoplasm
In Situ Carcinoma

  • Carcinoma In Situ
Ductal Carcinoma In Situ

  • Noninfiltrating Intraductal Carcinoma
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Tooth Agenesis

  • Oligodontia

  • Hypodontia

  • Selective Tooth Agenesis

  • Tooth Agenesis, Selective

  • Familial Tooth Agenesis

  • Anodontia

  • Congenital Absence Of One Tooth
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07440 KRT17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18530 Krt17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25012 Krt17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KRT17 VGNC VGNC:108193
Rattus norvegicus KRT17 RGD RGD:1303181
Canis familiaris KRT17 VGNC VGNC:55622
Mus musculus KRT17 MGD MGI:96691
Bos taurus KRT17 VGNC VGNC:50398
Others KRT17 NCBI