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Referencia número: HY-150908

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Brigatinib A

Brigatinib A is an GID4 ligand. Brigatinib A can be used for synthesizing PROTAC BCR-ABL Degrader-2 (HY-174368).

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No. CAS: 1197958-90-9
Fòrmula: C₂₃H₂₈ClN₆O₂P
Peso molecular:486.93

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Brigatinib A Chemical Structure

No. CAS: 1197958-90-9

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Brigatinib A is an GID4 ligand. Brigatinib A can be used for synthesizing PROTAC BCR-ABL Degrader-2 (HY-174368)^[1].

IC₅₀ & Target^[1]

EML4-ALK

Ver todos los productos específicos de isoformas EGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1975	IC₅₀	0.88 μM Compound: BA	Inhibition of cell viability in human NCI-H1975 cells incubated for 48 to 72 hrs by CCK8 assay Inhibition of cell viability in human NCI-H1975 cells incubated for 48 to 72 hrs by CCK8 assay	[PMID: 39114932]
NCI-H3122	IC₅₀	0.3 μM Compound: BA	Inhibition of cell viability in human NCI-H3122 cells incubated for 48 to 72 hrs by CCK8 assay Inhibition of cell viability in human NCI-H3122 cells incubated for 48 to 72 hrs by CCK8 assay	[PMID: 39114932]
SR	IC₅₀	1.6 nM Compound: 1	Antiproliferative activity against human SR cells assessed as reduction in cell growth Antiproliferative activity against human SR cells assessed as reduction in cell growth	[PMID: 32179332]

Chemical Information

No. CAS 1197958-90-9
Peso molecular 486.93
Fòrmula C₂₃H₂₈ClN₆O₂P
SMILES

COC1=CC(N2CCNCC2)=CC=C1NC3=NC=C(C(NC4=CC=CC=C4P(C)(C)=O)=N3)Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhang J, et al. Linker-free PROTACs efficiently induce the degradation of oncoproteins. Nat Commun. 2025 May 23;16(1):4794. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Actividad biológica
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- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias

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Brigatinib A

Ver todos los productos específicos de isoformas EGFR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Brigatinib A Related Classifications

HY-150908 Related Classifications