NOX-6-18
Based on 1 publication(s) in Google Scholar
NOX-6-18 (GPR132-B-160, Compound 25) is a GPR132 antagonist with an EC50 value of 0.075 μM. NOX-6-18 has promote insulin secretion activity with an EC50 value of 0.7 μM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.72%
- No. CAS: 898211-21-7
- Fòrmula: C18H17NO5S
- Peso molecular:359.40
-
Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NOX-6-18
More
Actividad biológica
EC50: 0.075 μM (GPR132); 0.7 μM (insulin secretion activity)[1].
Chemical Information
-
No. CAS 898211-21-7
-
Appearance Solid
-
Peso molecular 359.40
-
Fòrmula C18H17NO5S
-
Color White to off-white
-
SMILES
O=C(C1=C(C)C2=C(C=CC(S(=O)(NCCC3=CC=CC=C3)=O)=C2)O1)O
-
Synonyms
GPR132 antagonist 1
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Int Immunopharmacol
GPR132 drives macrophage M1 polarization and aggravates inflammation-associated liver injury. [Abstract]2026 Apr 1:174:116349. PMID: 41679180
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (278.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.96 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
-
Ficha de datos (270 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7824 mL | 13.9121 mL | 27.8242 mL | 69.5604 mL |
| 5 mM | 0.5565 mL | 2.7824 mL | 5.5648 mL | 13.9121 mL | |
| 10 mM | 0.2782 mL | 1.3912 mL | 2.7824 mL | 6.9560 mL | |
| 15 mM | 0.1855 mL | 0.9275 mL | 1.8549 mL | 4.6374 mL | |
| 20 mM | 0.1391 mL | 0.6956 mL | 1.3912 mL | 3.4780 mL | |
| 25 mM | 0.1113 mL | 0.5565 mL | 1.1130 mL | 2.7824 mL | |
| 30 mM | 0.0927 mL | 0.4637 mL | 0.9275 mL | 2.3187 mL | |
| 40 mM | 0.0696 mL | 0.3478 mL | 0.6956 mL | 1.7390 mL | |
| 50 mM | 0.0556 mL | 0.2782 mL | 0.5565 mL | 1.3912 mL | |
| 60 mM | 0.0464 mL | 0.2319 mL | 0.4637 mL | 1.1593 mL | |
| 80 mM | 0.0348 mL | 0.1739 mL | 0.3478 mL | 0.8695 mL | |
| 100 mM | 0.0278 mL | 0.1391 mL | 0.2782 mL | 0.6956 mL |
Powered by Bioz