Guanidinoethyl sulfonate (Standard)
Guanidinoethyl sulfonate (Standard) is the analytical standard of Guanidinoethyl sulfonate. This product is intended for research and analytical applications. Guanidinoethyl sulfonate is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury.
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- Pureza: 99.86%
- No. CAS: 543-18-0
- Fòrmula: C3H9N3O3S
- Peso molecular:167.19
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Product Information
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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No. CAS 543-18-0
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Appearance Solid
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Peso molecular 167.19
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Fòrmula C3H9N3O3S
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Color White to off-white
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SMILES
N=C(NCCS(=O)(O)=O)N
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Synonyms
Taurocyamine (Standard)
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Sergeeva OA, et al. Guanidinoethyl sulphonate is a glycine receptor antagonist in striatum. Br J Pharmacol. 2002 Nov;137(6):855-60. [Content Brief]
[2]. Igarashi H, et al. Guanidinoethane sulfate is neuroprotective towards delayed CA1 neuronal death in gerbils. Life Sci. 1995;56(14):1201-6. [Content Brief]
[3]. K Ejiri, et al. Effect of guanidinoethyl sulfonate on taurine concentrations and fetal growth in pregnant rats. Biol Neonate. 1987;51(4):234-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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