S16–1029
S16–1029 is a selective and orally active butyrylcholinesterase (BChE) inhibitor with IC50s of 11.35 nM and 48.1 nM for eqBChE and hBChE, respectively. S16–1029 could cross the blood-brain barrier (BBB) and reach the central nervous system (CNS). S16–1029 can be used for Alzheimer's disease (AD) research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2653349-51-8
- Fòrmula: C23H25N7O3
- Peso molecular:447.49
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
eqBCHE 11.35 nM (IC50) |
hBCHE 48.1 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| SH-SY5Y | IC50 |
89.77 μM
Compound: S16-1029
|
Cytotoxicity against human SH-SY5Y cells assessed as survival rate incubated for 24 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as survival rate incubated for 24 hrs by MTT assay
|
[PMID: 38452730] |
Chemical Information
-
No. CAS 2653349-51-8
-
Peso molecular 447.49
-
Fòrmula C23H25N7O3
-
SMILES
O=C(CN1C(C2=NON=C2N)=NC3=C1C=CC=C3)NC4=CC=C(CCN5CCOCC5)C=C4
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz