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Referencia número: HY-137922

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SHS4121705

SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC₅₀ of 4.3 μM in L6 myoblasts. SHS4121705 can be used in the study of non-alcoholic steatohepatitis (NASH).

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No. CAS: 2379550-82-8
Fòrmula: C₁₁H₆F₃N₅O₃
Peso molecular:313.19

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SHS4121705 Chemical Structure

No. CAS: 2379550-82-8

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Actividad biológica

Descripciòn

SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC₅₀ of 4.3 μM in L6 myoblasts. SHS4121705 can be used in the study of non-alcoholic steatohepatitis (NASH)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L6	EC₅₀	4.3 μM Compound: 12i; SHS4121705	Induction of mitochondrial uncoupling in rat L6 cells assessed as increase in oxygen consumption rate incubated for 90 mins by Seahorse XF analyzer based assay Induction of mitochondrial uncoupling in rat L6 cells assessed as increase in oxygen consumption rate incubated for 90 mins by Seahorse XF analyzer based assay	[PMID: 32392051]
L6	EC₅₀	4.3 μM Compound: SHS4121705	Induction of mitochondrial uncoupled respiration in rat L6 myoblasts assessed as increase in oxygen consumption rate measured by Agilent Seahorse XF analyzer Induction of mitochondrial uncoupled respiration in rat L6 myoblasts assessed as increase in oxygen consumption rate measured by Agilent Seahorse XF analyzer	[PMID: 35907607]
MCF7	EC₅₀	4.3 μM Compound: SHS4121705	Antiproliferative activity against human MCF7 assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 33569941]

In Vivo

SHS4121705 (25 mg/kg, orally, for 21 days) decreases liver triglyceride levels and improves liver markers in STAM mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2379550-82-8
Peso molecular 313.19
Fòrmula C₁₁H₆F₃N₅O₃
SMILES

O=C1N=C2C(N=C1NC3=CC=C(OC(F)(F)F)C=C3)=NON2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Salamoun JM, et al. 6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Jun 11;63(11):6203-6224. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SHS4121705

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