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ε-Poly-L-lysine hydrochloride (MV 2000-5000)

(Synonyms: Epsilon-polylysine hydrochloride (MV 2000-5000); ε-Polylysine hydrochloride (MV 2000-5000); ε-PL hydrochloride (MV 2000-5000))

ε-Poly-L-lysine (Epsilon-polylysine; ε-Polylysine) hydrochloride (MV 2000-5000) is a polycationic antibacterial agent with broad-spectrum activity against Gram-positive bacteria, Gram-negative bacteria, fungi, yeasts and specific bacteriophages. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exerts bactericidal effects through mechanisms such as disrupting microbial membranes, inducing ROS production, inhibiting metabolism and spore germination. ε-Poly-L-lysine hydrochloride (MV 2000-5000) also regulates the expression of multiple key genes including sodA, oxyR and recA. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exhibits properties such as low eukaryotic cytotoxicity, thermal stability and pH stability, and supports tissue regeneration and anti-tumor applications. ε-Poly-L-lysine hydrochloride (MV 2000-5000) can be applied in research fields including bacterial and fungal infections, diabetic ulcers, and methicillin-resistant Staphylococcus aureus infections.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99%
Fòrmula: (C₆H₁₂N₂O.ClH)n
Peso molecular:2000-5000

Almacenamiento:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ε-Poly-L-lysine hydrochloride (MV 2000-5000) Chemical Structure

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Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Bioz

Actividad biológica

Descripciòn

In Vitro

ε-Poly-L-lysine hydrochloride (MV 2000-5000) (2.5-12.5 μg/mL) inhibits spore germination of Geobacillus stearothermophilus at 2.5 μg/mL, and Bacillus coagulans and B. subtilis at 12.5 μg/mL^[1].
ε-Poly-L-lysine hydrochloride (MV 2000-5000) (500 μg/mL) significantly inactivates long-tailed, non-contractile double-stranded DNA bacteriophages, resulting in 0-27% survival rates^[1].
ε-Poly-L-lysine hydrochloride (MV 2000-5000) (25-200 μg/mL) inhibits Escherichia coli growth with an MIC of 25-50 μg/mL at pH 5.0-7.0, but its antimicrobial activity is significantly reduced at pH 8.0 (MIC >200 μg/mL)^[1].
ε-Poly-L-lysine hydrochloride (MV 2000-5000) exhibits a synergistic preservative effect when combined with 2 mg/mL glycine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Catechol/ε-PLL (ε-Poly-L-lysine hydrochloride (MV 2000-5000)) hydrogels reduce bacterial burden in mouse burn wound infections^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Peso molecular 2000-5000
Fòrmula (C₆H₁₂N₂O.ClH)n
Color White to off-white
SMILES

CNC([C@H](CCCCC)N)=O.[n].Cl
Synonyms

Epsilon-polylysine hydrochloride (MV 2000-5000); ε-Polylysine hydrochloride (MV 2000-5000); ε-PL hydrochloride (MV 2000-5000)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yoshida T, Nagasawa T. ε-Poly-l-lysine: microbial production, biodegradation and application potential[J]. Applied microbiology and biotechnology, 2003, 62(1): 21-26.

[2]. Lebaudy E, Guilbaud-Chéreau C, Frisch B, et al. The high potential of ε‐Poly‐l‐Lysine for the development of antimicrobial biomaterials[J]. Advanced NanoBiomed Research, 2023, 3(12):

[3]. Ye R, Xu H, Wan C, et al. Antibacterial activity and mechanism of action of ε-poly-l-lysine[J]. Biochemical and biophysical research communications, 2013, 439(1): 148-153.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Solvente y solubilidad
- In Vitro
- In Vivo Dissolution Calculator
Pureza y Documentación
Referencias

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ε-Poly-L-lysine hydrochloride (MV 2000-5000)

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Calculators

Help & FAQs

ε-Poly-L-lysine hydrochloride (MV 2000-5000) Related Classifications

Referencia número: HY-W250308A