CDH15 - cadherin 15 Gene

Homo sapiens

Also known as CDH3; CDHM; MCAD; MRD3; CDH14

Gene ID: 1013 | Gene type: protein coding

About CDH15

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,171,748-89,195,492 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues, 33 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]

CDH15 Products(1)

mRNA	Protein	Name
NM_004933.3	NP_004924.1	cadherin-15 preproprotein

CDH15 Protein Structure

Cadherin

Cadherin_C

0
200
400
600
814 a.a.

Protein Preferred Names

Protein Names

cadherin-15

cadherin 15, type 1, M-cadherin (myotubule)

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 3

MRD3	Autosomal Dominant Non-Syndromic Intellectual Disability 3
Mental Retardation, Autosomal Dominant 3	Autosomal Dominant Intellectual Developmental Disorder 3

Autosomal Dominant Non-Syndromic Intellectual Disability

Hypotrichosis, Congenital, With Juvenile Macular Dystrophy

HJMD	Congenital Hypotrichosis With Juvenile Macular Dystrophy
Hypotrichosis With Cone-Rod Dystrophy	Hypotrichosis With Juvenile Macular Dystrophy
Juvenile Macular Degeneration And Hypotrichosis	Juvenile Macular Dystrophy And Congenital Hypotrichosis
Hypotrichosis With Juvenile Macular Degeneration	Hypotrichosis Congenital With Juvenile Macular Dystrophy

Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome

Eem Syndrome	Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy
EEMS	Ectodermal Dysplasia-Ectrodactyly-Macular Dystrophy Syndrome
Albrectsen-Svendsen Syndrome	Ohdo-Hirayama-Terawaki Syndrome
Dysplasia, Ectodermal, Ectrodactyly, And Macular Dystrophy

Intellectual Developmental Disorder, Autosomal Dominant 4

MRD4	Autosomal Dominant Non-Syndromic Intellectual Disability 4
Mental Retardation, Autosomal Dominant 4	Autosomal Dominant Intellectual Developmental Disorder 4

Hypotrichosis 2

HYPT2	Hypotrichosis Simplex Of The Scalp 1
Htss1	Htss
Hypotrichosis, Spanish Type	Spanish Type Hypotrichosis
Hypotrichosis Spanish Type	Hypotrichosis, Type 2
Hypotrichosis Simplex Of Scalp

T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy

Winged Helix Deficiency	Alymphoid Cystic Thymic Dysgenesis
Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome	Pignata Guarino Syndrome
TIDAND	T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy
Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency	Severe Combined Immunodeficiency Due To Foxn1 Deficiency
Foxn1 Deficiency	Nude/Scid
Nude/Severe Combined Immunodeficiency	Scid Due To Foxn1 Deficiency
Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy

Craniofacial-Deafness-Hand Syndrome

CDHS	Craniofacial Deafness Hand Syndrome
Sommer-Young-Wee-Frye Syndrome	Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss
Craniofacial-Hearing Loss-Hand Syndrome

Hypotrichosis 11

HYPT11

Hypotrichosis, Type 11

Kbg Syndrome

KBGS	Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies
Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies	Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies
Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome	Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Hypotrichosis 8

HYPT8	Lah3
Hypotrichosis, Localized, Autosomal Recessive 3	Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis
Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis	Hypotrichosis Localized Autosomal Recessive 3
Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis	ARWH1
Hypotrichosis, Type 8

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02325	CDH15 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CDH15	VGNC	VGNC:70808
Felis catus	CDH15	VGNC	VGNC:60673
Canis familiaris	CDH15	VGNC	VGNC:39023
Rattus norvegicus	CDH15	RGD	RGD:1303000
Mus musculus	CDH15	MGD	MGI:106672
Bos taurus	CDH15	VGNC	VGNC:27094

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