RHOG - ras homolog family member G Gene

Also Known as ARHG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 391

About RHOG

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:3,826,978-3,840,959 (from NCBI)

This gene has 4 transcripts (splice variants), 248 orthologues and 22 paralogues. Broad expression in bone marrow (RPKM 74.8), spleen (RPKM 41.3) and 24 other tissues.

Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

RHOG Products (1)

mRNA Protein Name
NM_001665.4 NP_001656.2 rho-related GTP-binding protein RhoG

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables GTPase activity IDA
IDA: Inferred from direct assay
12376551 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12879077 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within Rac protein signal transduction IDA
IDA: Inferred from direct assay
12376551 GOA
acts upstream of or within Rho protein signal transduction IDA
IDA: Inferred from direct assay
12376551 GOA
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
12545154 GOA
involved in activation of GTPase activity IMP
IMP: Inferred from mutant phenotype
20679435 GOA
involved in cell chemotaxis IMP
IMP: Inferred from mutant phenotype
20679435 GOA
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12545154 GOA
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
20679435 GOA
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
21900250 GOA
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
21900250 GOA
Cellular Component GO Annotation Evidence Verweise Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21900250 GOA
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21900250 GOA
is active in postsynapse IDA
IDA: Inferred from direct assay
21900250 GOA
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
21900250 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOG Protein Structure

Ras

Ras: Ras family (5 - 177)

  • 0
  • 100
  • 191 a.a.
Protein Preferred Names Protein Names

rho-related GTP-binding protein RhoG

  • ras homolog gene family, member G (rho G)

RHOG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RHOG P84095 UNC13D Homo sapiens Q70J99
Pull Down
33513601
Intra
RHOG P84095 ELMO1 Homo sapiens Q92556
Anti Tag CoIP
12879077
Intra
RHOG P84095 ELMO1 Homo sapiens Q92556
Pull Down
33513601
Intra
RHOG P84095 ELMO1 Homo sapiens Q92556
Pull Down
12879077
Cross: Cross-species interaction Intra: Intraspecies interaction

RHOG Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P87051 RHOG Antibody (YA6744) WB, FC Human, Monkey

Related Diseases

Diseases Alias
Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis

  • Neutrophil Immunodeficiency Syndrome

  • IMD73A

  • Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis

  • Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis

  • Rac 2 Deficiency
Tangier Disease

  • Analphalipoproteinemia

  • High Density Lipoprotein Deficiency, Tangier Type

  • TGD

  • High Density Lipoprotein Deficiency, Type 1

  • Hdldt1

  • Familial High Density Lipoprotein Deficiency

  • A-Alphalipoprotein Neuropathy

  • Alpha High Density Lipoprotein Deficiency Disease

  • Cholesterol Thesaurismosis

  • Familial High Density Lipoprotein Deficiency Disease

  • Hdl Lipoprotein Deficiency Disease

  • Tangier Disease Neuropathy

  • Familial Alpha-Lipoprotein Deficiency

  • Familial High-Density Lipoprotein Deficiency 1

  • Primary Hypoalphalipoproteinemia 1

  • Analphalipo-Proteinemia

  • Familial Hypoalphalipo-Proteinemia

  • Familial Hypoalphalipoproteinemia

  • Lipoprotein Deficiency Disease, Hdl, Familial

  • Tangier Hereditary Neuropathy

  • Atp-Binding Cassette Transporter A1 Deficiency

  • Hdld1

  • High Density Lipoprotein Deficiency 1

  • Tangier Disease, Variant

  • Hypoalphalipoproteinemia, Familial

  • Familial Hdl Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11953 RHOG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21423 Rhog Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27941 Rhog Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RHOG VGNC VGNC:101390
Bos taurus RHOG VGNC VGNC:33949
Mus musculus RHOG MGD MGI:1928370
Rattus norvegicus RHOG RGD RGD:621310
Canis familiaris RHOG VGNC VGNC:45560
Felis catus RHOG VGNC VGNC:68107
Others RHOG NCBI