LHB - luteinizing hormone subunit beta Gene

Homo sapiens

Also known as CGB4; HH23; LSH-B; LSH-beta

Gene ID: 3972 | Gene type: protein coding

About LHB

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,015,980-49,019,498 (from NCBI)

This gene has 2 transcripts (splice variants), 27 orthologues, 9 paralogues and is associated with 2 phenotypes. Biased expression in pancreas (RPKM 1.7), testis (RPKM 1.1) and 7 other tissues.

Summary

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein Hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize Steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

LHB Products(1)

mRNA	Protein	Name
NM_000894.3	NP_000885.1	lutropin subunit beta precursor

LHB Protein Structure

Cys_knot

0
100
141 a.a.

Protein Preferred Names

Protein Names

lutropin subunit beta

interstitial cell stimulating hormone, beta chain

Related Diseases

Diseases

Alias

Hypogonadotropic Hypogonadism 23 With Or Without Anosmia

Fertile Eunuch Syndrome	Pasqualini Syndrome
HH23	46,Xy Disorder Of Sex Development Due To Lhb Deficiency
46,Xy Disorder Of Sex Development Due To Luteinizing Hormone Subunit Beta Deficiency	46,Xy Dsd Due To Lhb Deficiency
46,Xy Dsd Due To Luteinizing Hormone Subunit Beta Deficiency	Leydig Cell Hypoplasia Due To Lhb Deficiency
Leydig Cell Hypoplasia Due To Luteinizing Hormone Subunit Beta Deficiency	Eunuchoidism With Spermatogenesis, Normal Fsh And Low Or Normal Interstitial Cell-Stimulating Hormone
Hypogonadism, Hypogonadotropic, Type 23, With/Without Anosmia

Hypogonadism

Amenorrhea

Absence Of Menstruation

Amenia

Infertility

Hypogonadism, Male

Male Hypogonadism	Hypogonadism Male
Testicular Hypogonadism

Hypogonadotropic Hypogonadism

Klinefelter Syndrome	Klinefelter'S Syndrome
Xxy Syndrome	Xxy Trisomy
Hypogonadotropism	47, Xxy
Congenital Idiopathic Hypogonadotropic Hypogonadism	Isolated Congenital Gonadotropin Deficiency
47,Xxy Syndrome	47, Xxy Syndrome
Klinefelters Syndrome	Hypogonadism
Klinefelter Syndrome In Males	Klinefelter Syndrome, Unspecified
Klinefelter Syndrome Karyotype 47, Xxy

Drug Psychosis

Drug-Induced Psychosis	Drug-Induced Psychotic Disorder
Psychoses, Substance-Induced	Psychoses, Drug

Drug-Induced Mental Disorder

Substance-Induced Psychosis

Pseudohermaphroditism

Indeterminate Sex And Pseudohermaphroditism

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Leydig Cell Hypoplasia Type Ii

46,Xy Disorder Of Sex Developement Due To Partial Lh Receptor Inactivation	46,Xy Disorder Of Sex Developement Due To Partial Lh Resistance
46,Xy Disorder Of Sex Developement Due To Partial Luteinizing Hormone Resistance	46,Xy Dsd Due To Partial Lh Receptor Inactivation
46,Xy Dsd Due To Partial Lh Resistance	46,Xy Dsd Due To Partial Luteinizing Hormone Resistance
Leydig Cell Hypoplasia Due To Partial Lh Receptor Inactivation	Leydig Cell Hypoplasia Due To Partial Lh Resistance
Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Receptor Inactivation	Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Resistance
Leydig Cell Hypoplasia, Type Ii

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Hemophagocytic Lymphohistiocytosis, Familial, 3

Familial Hemophagocytic Lymphohistiocytosis 3	FHL3
Hplh3	Hlh3
Lymphohistiocytosis, Hemophagocytic, Familial, Type 3

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Mental Depression

Depression

Depressive Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07623	LHB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LHB	MGD	MGI:96782
Rattus norvegicus	LHB	RGD	RGD:3006
Others	LHB	NCBI