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27

Inhibitors & Agonists

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Isotope-Labeled Compounds

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Antibodies

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Click Chemistry

8

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14605A
    Rasagiline
    5+ Cited Publications

    (R)-AGN1135; TVP1012

    Monoamine Oxidase Neurological Disease
    Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Rasagiline
  • HY-14605
    Rasagiline mesylate
    5+ Cited Publications

    (R)-AGN1135 mesylate; TVP1012 mesylate

    Monoamine Oxidase Autophagy Apoptosis Neurological Disease
    Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Rasagiline mesylate
  • HY-104006

    Opioid Receptor Neurological Disease
    CYM51010 is a biased ligand of μ-opioid receptor – δ-opioid receptor heterodimers with an EC50 of 403 nM. CYM51010 exhibits anti-nociceptive activity similar to morphine but with a decreased levels of tolerance development and withdrawal symptoms .
    CYM51010
  • HY-P99835

    MABT 5102A; RG 7412

    Amyloid-β Neurological Disease
    Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, for use in Alzheimer's disease research .
    Crenezumab
  • HY-W517264

    BM 51052 hydrochloride

    Adrenergic Receptor Cardiovascular Disease
    Carazolol (BM 51052) hydrochloride is a highly potent antagonist of β12 adrenoceptor. Carazolol hydrochloride is also a potent, selective β3-adrenoceptor agonist. Carazolol hydrochloride can be used in the research of hypertension .
    Carazolol hydrochloride
  • HY-152849

    HL5101

    c-Met/HGFR Cancer
    Boditrectinib is a potent tyrosine kinase inhibitor. Boditrectinib serves as an antineoplastic agent. Boditrectinib is useful in the research of cancer, inflammation, neurodegenerative diseases and certain infectious diseases .
    Boditrectinib
  • HY-A0178

    AY 56012

    Histamine Receptor Endogenous Metabolite Inflammation/Immunology
    Isothipendyl (AY 56012), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist. Isothipendyl is a primary metabolite .
    Isothipendyl
  • HY-152849A

    HL5101 oxalate

    c-Met/HGFR Cancer
    Boditrectinib oxalate is a potent tyrosine kinase inhibitor. Boditrectinib oxalate serves as an antineoplastic agent. Boditrectinib oxalate is useful in the research of cancer, inflammation, neurodegenerative diseases and certain infectious diseases .
    Boditrectinib oxalate
  • HY-14605BS

    AGN1135-13C3; TVP1012-13C3 racemic

    Isotope-Labeled Compounds Monoamine Oxidase Neurological Disease
    Rasagiline- 13C3 (mesylate racemic) is a 13C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor . Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Rasagiline-13C3 mesylate racemic
  • HY-19163

    Integrin Cardiovascular Disease
    HY-19163 is an orally active fibrinogen receptor antagonist, with antiplatelet activities.
    SC-52012
  • HY-R03256

    MicroRNA Cancer
    mmu-miR-5112 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-5112 mimic
    mmu-miR-5112 mimic
  • HY-R03247

    MicroRNA Cancer
    mmu-miR-5101 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-5101 mimic
    mmu-miR-5101 mimic
  • HY-RI03256

    MicroRNA Cancer
    mmu-miR-5112 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-5112 inhibitor
    mmu-miR-5112 inhibitor
  • HY-117173

    AGN1135; (Rac)-TVP1012

    Monoamine Oxidase Neurological Disease
    (Rac)-Rasagiline (AGN1135) is the racemate of Rasagiline. (Rac)-Rasagiline is a selective type B MAO (MAO-B) inhibitor. (Rac)-Rasagiline can be used for Parkinson's disease research. (Rac)-Rasagiline protects against MPTP (HY-15608)-induced toxicity .
    (Rac)-Rasagiline
  • HY-14605AR

    (R)-AGN1135 (Standard); TVP1012 (Standard)

    Reference Standards Monoamine Oxidase Neurological Disease
    Rasagiline (Standard) is the analytical standard of Rasagiline. This product is intended for research and analytical applications. Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43?nM and 412?nM for rat brain MAO B and A activity, respectively . Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Rasagiline (Standard)
  • HY-14605R

    (R)-AGN1135 mesylate (Standard); TVP1012 mesylate (Standard)

    Reference Standards Monoamine Oxidase Autophagy Apoptosis Neurological Disease
    Rasagiline (mesylate) (Standard) is the analytical standard of Rasagiline (mesylate). This product is intended for research and analytical applications. Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43?nM and 412?nM for rat brain MAO B and A activity, respectively . Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Rasagiline mesylate (Standard)
  • HY-14605S

    (R)-AGN1135-13C3 mesylate; TVP1012-13C3 mesylate

    Isotope-Labeled Compounds Autophagy Monoamine Oxidase Apoptosis Others
    Rasagiline- 13C3 ((R)-AGN1135- 13C3; TVP1012- 13C3) mesylate is the deuterium labeled Rasagiline (mesylate) (HY-14605) . Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively .
    Rasagiline-13C3 mesylate
  • HY-104006R

    Reference Standards Opioid Receptor Neurological Disease
    CYM51010 (Standard) is the analytical standard of CYM51010 (HY-104006). This product is intended for research and analytical applications. CYM51010 is a biased ligand of μ-opioid receptor – δ-opioid receptor heterodimers with an EC50 of 403 nM. CYM51010 exhibits anti-nociceptive activity similar to morphine but with a decreased levels of tolerance development and withdrawal symptoms .
    CYM51010 (Standard)
  • HY-105146

    Others Inflammation/Immunology
    DF-1012 is an orally active anti-inflammatory agent and can inhibits cough .
    DF-1012
  • HY-180355

    CDK Ser/Thr Kinase c-Myc Apoptosis Cancer
    SY-5102 is a potent, selective and orally active cyclin-dependent kinase (CDK7) inhibitor with a Kd of 0.03 nM. SY-5102 shows anti-proliferative activity against HCC70 cells with an EC50 of 9 nM. SY-5102 can inhibit CDK7-mediated CAK function (downregulate CDK2 Thr160 phosphorylation) and TFIIH transcription function (downregulate RNA polymerase II Ser5 phosphorylation). SY-5102 can induce G2/M cell cycle arrest, downregulate the expression of the oncogene c-Myc, and ultimately trigger cancer cell apoptosis. SY-5102 can be used for the research of triple-negative breast cancer (TNBC) .
    SY-5102
  • HY-W879508

    BXT-51072

    Cytochrome P450 Glutathione Peroxidase Inflammation/Immunology
    ALT-2074 (BXT-51071) is an orally active catalytic analogue of glutathione peroxidase. ALT-2074 is an inhibitor of human CYP3A, with its IC50 value ranging from 2.0 to 2.6 μM. ALT-2074 shows only a weak inhibitory effect on CYP3A in vivo, suggesting that it may not significantly affect the metabolism of CYP3A substrate drugs. ALT-2074 can be used to study inflammatory diseases characterized by reactive oxygen species, such as acute coronary syndrome .
    ALT-2074
  • HY-R03247A

    MicroRNA Cancer
    mmu-miR-5101 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-5101 agomir
    mmu-miR-5101 agomir
  • HY-RI03256A

    MicroRNA Cancer
    mmu-miR-5112 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-5112 antagomir
    mmu-miR-5112 antagomir
  • HY-RI03247

    MicroRNA Cancer
    mmu-miR-5101 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-5101 inhibitor
    mmu-miR-5101 inhibitor
  • HY-R03256A

    MicroRNA Cancer
    mmu-miR-5112 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-5112 agomir
    mmu-miR-5112 agomir
  • HY-RI03247A

    MicroRNA Cancer
    mmu-miR-5101 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-5101 antagomir
    mmu-miR-5101 antagomir
  • HY-180328

    NK-1012-1

    Antibiotic Bacterial Endogenous Metabolite Infection
    3''-Deamino-3''-hydroxykanamycin B (NK-1012-1) is a kanamycin antibiotic. 3''-Deamino-3''-hydroxykanamycin B can be produced by S. tenebrarius. 3''-Deamino-3''-hydroxykanamycin B is effective against E. coli ATCC 25922 and E. coli CCARM 1A020, with MIC values of 128 μg/mL .
    3''-Deamino-3''-hydroxykanamycin B

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