PRCP - prolylcarboxypeptidase Gene

Also Known as PCP; HUMPCP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5547

About PRCP

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:82,822,936-82,901,644 (from NCBI)

This gene has 37 transcripts (splice variants), 199 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 42.6), urinary bladder (RPKM 37.6) and 25 other tissues.

Summary

This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal Amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

PRCP Products (3)

mRNA Protein Name
NM_001319214.2 NP_001306143.1 lysosomal Pro-X carboxypeptidase isoform 3
NM_005040.4 NP_005031.1 lysosomal Pro-X carboxypeptidase isoform 1 preproprotein
NM_199418.4 NP_955450.2 lysosomal Pro-X carboxypeptidase isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20517885 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRCP Protein Structure

Peptidase_S28

Peptidase_S28: Serine carboxypeptidase S28 (55 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
Protein Preferred Names Protein Names

lysosomal Pro-X carboxypeptidase

  • angiotensinase C

PRCP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRCP P42785 GPR37L1 Homo sapiens O60883
Protease Assay
20517885
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRCP Proteins

Cat. No. Product Name Accession Purity
HY-P7668 PRCP Protein, Human (HEK293, His) P42785 (L22-H496) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pyruvate Kinase Deficiency Of Red Cells

  • Pyruvate Kinase Deficiency

  • Pk Deficiency

  • Pyruvate Kinase Deficiency Of Erythrocyte

  • Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency

  • Pyruvate Kinase Deficiency Of Erythrocytes

  • Pkd

  • PKRD

  • Hereditary Non-Spherocytic Hemolytic Anemia Due To Pyruvate Kinase Deficiency

  • Hnsha

  • Pyruvate Kinase-Deficient Hemolytic Anemia

  • Red Cell Pyruvate Kinase Deficiency

  • Deficiency Of Pyruvate Kinase

  • Anemia, Hemolytic, Congenital Nonspherocytic
High Molecular Weight Kininogen Deficiency

  • HMWK DEFICIENCY

  • Fitzgerald Trait

  • Congenital High-Molecular-Weight Kininogen Deficiency

  • Flaujeac Factor Deficiency

  • Kininogen Deficiency, High Molecular Weight

  • Kininogen Deficiency

  • Hmwk

  • High-Molecular-Weight Kininogen Deficiency, Congenital
Congenital Nonspherocytic Hemolytic Anemia

  • Hereditary Non-Spherocytic Hemolytic Anemia

  • Hereditary Nonspherocytic Hemolytic Anemia

  • Anemia, Hemolytic, Congenital Nonspherocytic

  • Congenital Nonspherocytic Hemolytic Anaemia

  • Hereditary Nonspherocytic Hemolytic Anaemia

  • Hnsha
Hereditary Angioedema

  • Hereditary Angioneurotic Edema

  • Hereditary Angioedema Type 1

  • Hane

  • Angioedema, Hereditary

  • Hae

  • Angioedemas, Hereditary

  • Deficiency Of C1 Esterase Inhibitor

  • C1 Esterase Inhibitor Deficiency

  • C1 Inhibitor Deficiency

  • Familial Angioneurotic Edema

  • Hereditary Bradykinine-Induced Angioedema

  • Hereditary Non Histamine-Induced Angioedema

  • Hae 1

  • Hae-I

  • Hereditary Angioneurotic Edema Type 1

  • Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

  • Hereditary Angioedema Types I And Ii

  • Hereditary Angioneurotic Oedema

  • Familial Angioedema

  • Hae - [Hereditary Angioneurotic Oedema]

  • Bannister Disease, Hereditary

  • Quincke Disease Or Oedema

  • Hereditary Quincke Oedema
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-177760 PrCP-7414 / Unkown
HY-RS11058 PRCP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20801 Prcp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27315 Prcp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PRCP VGNC VGNC:33287
Felis catus PRCP VGNC VGNC:69032
Canis familiaris PRCP VGNC VGNC:44943
Macaca mulatta PRCP VGNC VGNC:76390
Rattus norvegicus PRCP RGD RGD:1307842
Mus musculus PRCP MGD MGI:1919711
Others PRCP NCBI