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RPS28 - ribosomal protein S28 Gene

Also Known as S28; eS28; DBA15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6234

About RPS28

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,321,496-8,323,340 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 563.4), spleen (RPKM 434.5) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS28 Products (1)

mRNA	Protein	Name
NM_001031.5	NP_001022.1	40S ribosomal protein S28

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	18697920	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA
involved in rRNA processing	IMP IMP: Inferred from mutant phenotype	18697920	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in ribosomal small subunit biogenesis	IMP IMP: Inferred from mutant phenotype	18697920	GOA
involved in ribosome biogenesis	IMP IMP: Inferred from mutant phenotype	24942156	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
located in ribosome	IDA IDA: Inferred from direct assay	25957688	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS28 Protein Structure

Ribosomal_S28e

0
69 a.a.

Protein Preferred Names	Protein Names
40S ribosomal protein S28	small ribosomal subunit protein eS28

RPS28 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPS28	P62857	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	RPS28	P62857	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	RPS28	P62857	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	RPS28	P62857	KRTAP2-3	Homo sapiens	P0C7H8	Y2H Array	25416956
Intra	RPS28	P62857	KRTAP2-3	Homo sapiens	P0C7H8	Y2H Prey Pooling	25416956
Intra	RPS28	P62857	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	RPS28	P62857	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	RPS28	P62857	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	RPS28	P62857	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	RPS28	P62857	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	RPS28	P62857	CCNDBP1	Homo sapiens	O95273	Y2H Array	25416956
Intra	RPS28	P62857	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
Intra	RPS28	P62857	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	RPS28	P62857	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis	DBA15 Diamond Blackfan Anemia 15 With Mandibulofacial Dysostosis Diamond-Blackfan Anemia 15, With Mandibulofacial Dysostosis Diamond-Blackfan Anemia With Microtia And Cleft Palate Anemia, Diamond Blackfan, Type 15 With Mandibulofacial Dysostosis
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Macrocytic Anemia	Anemia Macrocytic Anemia, Macrocytic Macrocytic Anaemia
Diamond-Blackfan Anemia 10	DBA10 Rps26-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 10
Chromosome 5q Deletion Syndrome	5q- Syndrome Mar Myelodysplastic Syndrome Associated With Isolated Del Chromosome Abnormality Macrocytic Anemia, Refractory, Due To 5q Deletion, Somatic 5q Deletion Syndrome 5q Minus Syndrome Refractory Macrocytic Anemia Due To 5q Deletion Myelodysplastic Syndrome With Isolated Del Macrocytic Anemia, Refractory, Due To 5q Deletion 5q- Syndrome, Refractory Macrocytic Anemia Due To 5q Deletion 5q Syndrome Chromosome 5q Deletion Myelodysplastic Syndrome With 5q Deletion Myelodysplastic Syndrome With 5q Deletion Syndrome Anemia, Macrocytic, Refractory, Due To 5q Deletion, Somatic 5q-Syndrome Chromosome 5, Trisomy 5q Loss Of Chromosome 5q 5 Q- Syndrome
Erythrasma	Infection Due To Corynebacterium Minutissimum
Dysostosis	Dysostoses
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12240	RPS28 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPS28	VGNC	VGNC:80709
Mus musculus	RPS28	MGD	MGI:1859516
Rattus norvegicus	RPS28	RGD	RGD:621046
Bos taurus	RPS28	VGNC	VGNC:34136
Canis familiaris	RPS28	VGNC	VGNC:108256
Others	RPS28	NCBI