FBXO11 - F-box protein 11 Gene

Also Known as UBR6; VIT1; FBX11; PRMT9; IDDFBA; UG063H01

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80204

About FBXO11

Cytogenetic location: 2p16.3 Genomic coordinates (GRCh38): 2:47,806,920-47,906,498 (from NCBI)

This gene has 18 transcripts (splice variants), 135 orthologues, 1 paralogue and is associated with 132 phenotypes. Ubiquitous expression in testis (RPKM 26.4), brain (RPKM 21.6) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

FBXO11 Products (3)

mRNA	Protein	Name
NM_001190274.2	NP_001177203.1	F-box only protein 11 isoform 4
NM_001374325.1	NP_001361254.1	F-box only protein 11 isoform 1
NM_025133.4	NP_079409.3	F-box only protein 11 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17098746	GOA
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	16487488	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	25827072	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	25827072	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	25827072	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	29059170	GOA
involved in protein modification process	IDA IDA: Inferred from direct assay	16487488	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16487488	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	25827072	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16487488	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO11 Protein Structure

F-box-like

Beta_helix

zf-UBR

0
200
400
600
800
927 a.a.

Protein Preferred Names	Protein Names
F-box only protein 11	protein arginine N-methyltransferase 9

FBXO11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FBXO11	Q86XK2	SNAI1	Homo sapiens	O95863	Anti Bait CoIP	25203322
Intra	FBXO11	Q86XK2	SKP1	Homo sapiens	P63208	Anti Tag CoIP	22632967
Intra	FBXO11	Q86XK2	SKP1	Homo sapiens	P63208	Anti Tag CoIP	17098746
Intra	FBXO11	Q86XK2	SKP1	Homo sapiens	P63208	Anti Tag CoIP	33961781
Intra	FBXO11	Q86XK2	SKP1	Homo sapiens	P63208	Y2H Prey Pooling	25416956
Intra	FBXO11	Q86XK2	SKP1	Homo sapiens	P63208-1	Anti Bait CoIP	22113614
Intra	FBXO11	Q86XK2	SKP1	Homo sapiens	P63208-1	Anti Tag CoIP	22113614
Intra	FBXO11	Q86XK2	TP53	Homo sapiens	P04637	Pull Down	17098746
Intra	FBXO11	Q86XK2	TP53	Homo sapiens	P04637	Anti Bait CoIP	17098746
Intra	FBXO11	Q86XK2	BCL6	Homo sapiens	P41182	Anti Tag CoIP	22113614
Intra	FBXO11	Q86XK2	BCL6	Homo sapiens	P41182	Anti Bait CoIP	22113614

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder With Dysmorphic Facies And Behavioral Abnormalities	IDDFBA Intellectual Developmental Disorder, Dysmorphic Facies, Behavioral Abnormalities
Otitis Media	Opsoclonus-Myoclonus Syndrome OMS Otitis Media, Susceptibility To Kinsbourne Syndrome Otitis Media, Chronic/Recurrent Come/Rom Ataxo-Opso-Myoclonus Syndrome Dancing Eye Syndrome Dancing Eye-Dancing Feet Syndrome Oma Syndrome Opsoclonus Myoclonus Syndrome Opsoclonus-Myoclonus-Ataxia Syndrome Poma Syndrome Paraneoplastic Opsoclonus-Myoclonus Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome Opsoclonus Myoclonus OM {Otitis Media, Susceptibility To} Infectious Otitis Media
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Chronic Purulent Otitis Media	Chronic Suppurative Otitis Media Csom - [Chronic Suppurative Otitis Media]
Suppurative Otitis Media	Otitis Media With Effusion - Purulent Purulent Otitis Media Otitis Media, Suppurative
Middle Ear Disease	Middle Ear Anomaly Disorder Of Middle Ear
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Tympanosclerosis	Ts - [Tympanosclerosis] Tympanic Membrane Sclerosis
Tympanic Membrane Disease	Disorder Of Tympanic Membrane
Adhesive Otitis Media	Adhesive Middle Ear Disease Chronic Adhesive Otitis Media Adhesive Otitis Fibrotic Adhesive Otitis Media Adhesive Disorder Of Middle Ear
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Optic Nerve Hypoplasia, Bilateral	Optic Nerve Hypoplasia Bilateral Optic Nerve Hypoplasia Optic Nerve Hypoplasia, Familial Bilateral Familial Bilateral Optic Nerve Hypoplasia Isolated Optic Nerve Hypoplasia/Aplasia Optic Nerve Aplasia, Bilateral Onh BONH Bilateral Optic Nerve Aplasia Hypoplasia, Optic Nerve, Bilateral
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04795	FBXO11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21855	Fbxo11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FBXO11	VGNC	VGNC:28892
Rattus norvegicus	FBXO11	RGD	RGD:727935
Macaca mulatta	FBXO11	VGNC	VGNC:72493
Felis catus	FBXO11	VGNC	VGNC:62176
Mus musculus	FBXO11	MGD	MGI:2147134
Canis familiaris	FBXO11	VGNC	VGNC:40762
Others	FBXO11	NCBI