Uchl1 - ubiquitin C-terminal hydrolase L1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29545

Summary

Predicted to enable several functions, including alpha-2A Adrenergic Receptor binding activity; cysteine-type peptidase activity; and ubiquitin protein Ligase binding activity. Involved in sensory perception of pain and ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including neuron projection terminus; neuronal cell body; and nucleoplasm. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1). [provided by Alliance of Genome Resources, Apr 2022]

Uchl1 Products (1)

mRNA Protein Name
NM_017237.4 NP_058933.2 ubiquitin carboxyl-terminal hydrolase isozyme L1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
11850463 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase isozyme L1

  • PGP 9.5

  • PGP9.5

  • UCH-L1

  • neuron cytoplasmic protein 9.5

  • ubiquitin carboxy-terminal hydrolase L1

  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

  • ubiquitin thioesterase L1

Recombinant Uchl1 Proteins

Cat. No. Product Name Accession Purity
HY-P74483 UCHL1 Protein, Rat (His) Q00981 (Q2-A223) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153627 GK13S Inhibitor 99.09% Unkown
HY-161378 UCHL1-IN-1 Inhibitor 98.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Uchl1 NCBI NCBI:7345
Mus musculus Uchl1 NCBI NCBI:22223